The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia
Open accessAbstract
Poly(ADP-ribose) polymerase-1 (PARP-1, EC 2.4.2.30 ), a nuclear enzyme activated by DNA strand breaks, physiologically participates in DNA repair. Excessive activation of PARP-1 by cellular insults depletes its substrate β-nicotinamide adenine dinucleotide and ATP, leading to cell death. PARP-1-deficient (PARP-1 −/− ) mice are protected from several forms of inflammation. In the present study, we demonstrate in PARP-1 −/− glial cells a loss of several stress-activated transcription factors as well as decreased expression of genes for cytokines and cellular adhesion molecules. We also show that augmented expression of some of these genes is independent of PARP-1 catalytic activity. These findings indicate that PARP-1 plays a pivotal role in the initial inflammatory response by modulating transcription of inflammation-linked genes.
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Cites
NF-kB: a crucial transcription factor for glial and neuronal cell function
O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 1,013
A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation
Hassa, P. O., & Hottiger, M. O. (1999) · Biological Chemistry · doi:10.1515/bc.1999.118 · Cited by 296
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Metadata
- Authors
- Ha, H. C., Hester, L. D., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-02-19
- Volume
- 99
- Issue
- 5
- Pages
- 3270-3275
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2075454634
- Cited by
- 253
- References
- 2
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Ha, H. C., Hester, L. D., & Snyder, S. H. (2002). Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.052712399
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
