Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., Ward, Robyn L., Hawkins, Nicholas J., Quinn, David I., Russell, Pamela J., Sutherland, Robert L., Breit, Samuel N., Moskaluk, Christopher A., Frierson, Henry F., Hampton, Garret M.·2003·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0530278100

Cited by (504)

Items 101–200 of 504

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Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts
Ramirez, Jean‐Marie, Schaad, Olivier, Durual, Stephane, Cossali, Dominique, Docquier, Mylène, Beris, Photis, Descombes, Patrick, Matthes, Thomas · 2009 · British Journal of Haematology
Selective binding and enrichment for low‐molecular weight biomarker molecules in human plasma after exposure to nanoporous silica particles
Rosa Terracciano, Marco Gaspari, Flaviano Testa, Luigi Pasqua, Pierosandro Tagliaferri, Mark Ming‐Cheng Cheng, A. Jasper Nijdam, Emanuel F. Petricoin, Lance A. Liotta, Giovanni Cuda et al. · 2006 · PROTEOMICS
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Maria Kalli, Panagiotis Papageorgis, Vasiliki Gkretsi, Triantafyllos Stylianopoulos · 2018 · Annals of Biomedical Engineering
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Quirin Notz, Marc Schmalzing, Florian Wedekink, Tobias Schlesinger, Michael Gernert, Johannes Herrmann, Lena Sorger, Dirk Weismann, Benedikt Schmid, Magdalena Sitter et al. · 2020 · Frontiers in Immunology
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Lijiao Ao, Tao Liao, Liang Huang, Shan Lin, Kui Xu, Jiangtao Ma, Shaorong Qiu, Xiangyu Wang, Qiqing Zhang · 2022 · Chemical Engineering Journal
The GDNF Family: A Role in Cancer?
Graeme C. Fielder, Teresa Wen-Shan Yang, Mahalakshmi Razdan, Yan Li, Jun Lu, Jo Kate Perry, Peter Edward Lobie, Dong‐Xu Liu · 2017 · Neoplasia
Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI
Vicky Wang-Wei Tsai, Laurence Macia, Christine Feinle‐Bisset, Rakesh Manandhar, Arne Vernon Astrup, Anne Raben, Janne K. Lorenzen, Peter Thelin Schmidt, Fredrik E. Wiklund, Nancy L. Pedersen et al. · 2015 · PLoS ONE
Serum Macrophage Inhibitory Cytokine-1 Concentrations Correlate with the Presence of Prostate Cancer Bone Metastases
Katri S. Selander, David Alexander Brown, Guillermo Blanco Sequeiros, Mark I Hunter, Renée A. Desmond, Teija M Parpala, Juha Risteli, Samuel N. Breit, Arja Jukkola‐Vuorinen · 2007 · Cancer Epidemiology Biomarkers & Prevention
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Amy A. Worth, Rosemary Shoop, Katie Tye, Claire H. Feetham, Giuseppe D’Agostino, Garron T. Dodd, Frank M. Reimann, Fiona Mary Gribble, Emily Beebe, James D. Dunbar et al. · 2020 · eLife
Growth differentiation factor-15 and its role in diabetes and cardiovascular disease
Adrian C. Eddy, Aaron J. Trask · 2020 · Cytokine & Growth Factor Reviews
Gene expression changes during HPV‐mediated carcinogenesis: A comparison between an in vitro cell model and cervical cancer
Fang Wan, Xijiang Miao, Iram Quraishi, Valerie Kennedy, Kim E. Creek, Lucia A. Pirisi · 2008 · International Journal of Cancer
The Role of Inflammation in Prostate Cancer
Karen Sandell Sfanos, Heidi Hempel, Angelo Michael De Marzo · 2014 · Advances in experimental medicine and biology
GDF15 knockdown promotes erastin-induced ferroptosis by decreasing SLC7A11 expression
Liang Chen, Linlin Qiao, Yue Bian, Xiuju Sun · 2020 · Biochemical and Biophysical Research Communications
Applications of a Rat Multiple Tissue Gene Expression Data Set
John R. Walker, Andrew I. Su, David W. Self, John B. Hogenesch, Hilmar Lapp, Rainer M. Maier, Daniël Hoyer, Graeme Bilbe · 2004 · Genome Research
Molecular Mechanisms of Trastuzumab-Based Treatment in HER2-Overexpressing Breast Cancer
Rita Nahta · 2012 · ISRN Oncology
Systemic effects of mitochondrial stress
Raz Bar‐Ziv, Theodore Bolas, Andrew G. Dillin · 2020 · EMBO Reports
Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway
Samuel N. Breit, Vicky Wang-Wei Tsai, David Alexander Brown · 2017 · Trends in Molecular Medicine
Anorexia/cachexia of chronic diseases: a role for the TGF‐β family cytokine MIC‐1/GDF15
Vicky Wang-Wei Tsai, Yasmin Husaini, Rakesh Manandhar, Ka Ki Michelle Lee-Ng, Hong Ping Zhang, Kate Harriott, Lele Jiang, Shu Lin, Amanda Sainsbury, David Alexander Brown et al. · 2012 · Journal of Cachexia Sarcopenia and Muscle
Biomarkers of ovarian tumours
Amy Rapkiewicz, Virginia A. Espina, Emanuel F. Petricoin, Lance A. Liotta · 2004 · European Journal of Cancer
The expression landscape of cachexia‐inducing factors in human cancers
Paula Paccielli Freire, Geysson Javier Fernández, Diogo de Moraes, Sarah Santiloni Cury, Maeli Dal‐Pai‐Silva, Patrícia P. Reis, Sílvia Regina Rogatto, Robson Francisco Carvalho · 2020 · Journal of Cachexia Sarcopenia and Muscle
Protein Kinase C-dependent Regulation of NAG-1/Placental Bone Morphogenic Protein/MIC-1 Expression in LNCaP Prostate Carcinoma Cells
Minsub Shim, Thomas E. Eling · 2005 · Journal of Biological Chemistry
Proteomics-based identification of secreted protein dihydrodiol dehydrogenase as a novel serum markers of non-small cell lung cancer
Lingjin Huang, Shengxi Chen, Yan Huang, Wanjun Luo, Haihe Jiang, Qinghua Hu, Pengfei Zhang, Hong Liang Yi · 2006 · Lung Cancer
GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH
Kook Hwan Kim, Myung‐Shik Lee · 2020 · Biochimica et Biophysica Acta (BBA) - General Subjects
Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model
Jung Eun Kim, Kyung Hee Koo, Yeul Hong Kim, Jeongwon Sohn, Yun Gyu Park · 2008 · Experimental & Molecular Medicine
Elevated Plasma Growth Differentiation Factor-15 Correlates with Lymph Node Metastases and Poor Survival in Endometrial Cancer
Anne Cathrine Staff, Jone Trovik, Eriksson Ane Gerda Zahl, Elisabeth Wik, Kai Christoph Wollert, Tibor Kempf, Helga Birgitte Salvesen · 2011 · Clinical Cancer Research
Characterization of Arecoline-Induced Effects on Cytotoxicity in Normal Human Gingival Fibroblasts by Global Gene Expression Profiling
Shang‐Lun Chiang, Shih Sheng Jiang, Yi-Jou Wang, Horn-Che Chiang, Ping‐Ho Chen, Hung‐Pin Tu, Kun‐Yen Ho, Yu-Shan Tsai, I‐Shou Chang, Ying‐Chin Ko · 2007 · Toxicological Sciences
Prostate‐derived factor as a paracrine and autocrine factor for the proliferation of androgen receptor‐positive human prostate cancer cells
Siu-Ju Chen, Dev Karan, Sonny L. Johansson, Fen‐Fen Lin, Jeffrey M. Zeckser, Ajay P. Singh, Surinder K. Batra, Ming‐Fong Lin · 2007 · The Prostate
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome
Jonathan L. Robinson, Amir Feizi, Mathias Uhlén, Jens Nielsen · 2019 · Cell Reports
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Jeffrey Crawford, Roberto A. Calle, Susie M. Collins, Yan Weng, Shannon L. Lubaczewski, Clare Buckeridge, Ellen Q. Wang, Magdalena Alicja Harrington, Anil Tarachandani, Michelle I. Rossulek et al. · 2023 · Clinical Cancer Research
Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics
Da‐elene van der Merwe, Κατερίνα Οικονομοπούλου, John G. Marshall, Eleftherios P. Diamandis · 2006 · Advances in cancer research
Proteomic Profiling of Serum-Derived Exosomes from Ethnically Diverse Prostate Cancer Patients
David Turay, Salma Khan, Carlos Joel Diaz Osterman, Matthew P. Curtis, Balreet Khaira, Jonathan W. Neidigh, Saied Mirshahidi, Carlos A. Casiano, Nathan R. Wall · 2015 · Cancer Investigation
Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells
Jayashree P. Joshi, Nicole E. Brown, Samantha E. Griner, Rita Nahta · 2011 · Biochemical Pharmacology
GDF-15 protects from macrophage accumulation in a mousemodel of advanced atherosclerosis
Michael R. Preusch, Matthias Baeuerle, Claudia Albrecht, Erwin Blessing, Marc Bischof, Hugo Albert Katus, Florian Bea · 2013 · European journal of medical research
Using Aptamers for Cancer Biomarker Discovery
Yun Min Chang, Michael J. Donovan, Weihong Tan · 2013 · Journal of Nucleic Acids
ALX1 Induces Snail Expression to Promote Epithelial-to-Mesenchymal Transition and Invasion of Ovarian Cancer Cells
Hong Yuan, Hiroaki Kajiyama, Satoko Ito, Nobuhisa Yoshikawa, Toshinori Hyodo, Eri Asano, Hitoki Hasegawa, Masao Maeda, Kiyosumi Shibata, Michinari Hamaguchi et al. · 2013 · Cancer Research
Aberrant Neuropeptide Y and Macrophage Inhibitory Cytokine-1 Expression Are Early Events in Prostate Cancer Development and Are Associated with Poor Prognosis
Krishan Rasiah, James G. Kench, Margaret Gardiner‐Garden, Andrew Victor Biankin, David Golovsky, Phillip C. Brenner, Raji Kooner, Gordon O’Neill, Jennifer Turner, Warick Delprado et al. · 2006 · Cancer Epidemiology Biomarkers & Prevention
Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling
Bridgette F. Peake, Siobhan M. Eze, Lily P H Yang, Robert Craig Castellino, Rita Nahta · 2017 · Oncotarget
A Boolean-based systems biology approach to predict novel genes associated with cancer: Application to colorectal cancer
Shivashankar Hiriyur Nagaraj, Antônio Reverter · 2011 · BMC Systems Biology
Growth/differentiation factor-15: prostate cancer suppressor or promoter?
Petr Vaňhara, Aleš Hampl, Alois Kozubík, Karel Souček · 2012 · Prostate Cancer and Prostatic Diseases
Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer
Chen Li, Xiaobing Wang, José Ignacio Casal, Jingyu Wang, Peiwei Li, Wei Zhang, Enping Xu, Maode Lai, Honghe Zhang · 2016 · Journal of Cellular and Molecular Medicine
Dysregulated expression of MIC-1/PDF in human prostate tumor cells
Dev Karan, Siu-Ju Chen, Sonny L. Johansson, Ajay P. Singh, Vishwas M. Paralkar, Ming‐Fong Lin, Surinder K. Batra · 2003 · Biochemical and Biophysical Research Communications
Gene Expression Profiling of Human Cancers
Giselda Bucca, Giuseppe Carruba, Annalisa Saetta, Paula Muti, LUIGI A. M. CASTAGNETTA, Colin P. Sambrook Smith · 2004 · Annals of the New York Academy of Sciences
The TGF-β Superfamily Cytokine MIC-1/GDF15: Secretory Mechanisms Facilitate Creation of Latent Stromal Stores
Asne R. Bauskin, Lele Jiang, Xiaohe Luo, Liyun Wu, David Alexander Brown, Samuel N. Breit · 2010 · Journal of Interferon & Cytokine Research
YAP promotes breast cancer metastasis by repressing growth differentiation factor-15
Ting Wang, Beibei Mao, Chi Cheng, Zhuangzhi Zou, Junling Gao, Yanglu Yang, Tong Lei, Xiaolong Qi, Zengqiang Yuan, Wentong Xu et al. · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
A Multiparametric Panel for Ovarian Cancer Diagnosis, Prognosis, and Response to Chemotherapy
Yingye Zheng, Dionyssios Katsaros, Shannon J.C. Shan, Irene A. Rigault de la Longrais, Mauro Porpiglia, Andreas Scorilas, Nam W. Kim, Robert L. Wolfert, Iris Simón, Lin Li et al. · 2007 · Clinical Cancer Research
Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion
Samantha E. Griner, Jayashree P. Joshi, Rita Nahta · 2012 · Biochemical Pharmacology
Serum Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15): A Potential Screening Tool for the Prevention of Colon Cancer?
David Alexander Brown, Kenneth W. Hance, Connie Jo Rogers, Leah B. Sansbury, Paul S. Albert, Gwen A Murphy, Adeyinka O. Laiyemo, Zhuoqiao Wang, Amanda Jane Cross, Arthur G. Schatzkin et al. · 2012 · Cancer Epidemiology Biomarkers & Prevention
Histological coherent Raman imaging: a prognostic review
Marcus T. Cicerone, Charles H. Camp · 2017 · The Analyst
Identification of diagnostic serum protein profiles of glioblastoma patients
Anja Elstner, Florian Stockhammer, Trong-Nghia Nguyen-Dobinsky, Quang Long Nguyen, Ingo Pilgermann, Amanjit Gill, Anke Guhr, Tingguo Zhang, Kajetan von Eckardstein, Thomas Picht et al. · 2010 · Journal of Neuro-Oncology
Computational prediction of human proteins that can be secreted into the bloodstream
Juan Cui, Qi Liu, David Puett, Ying Xu · 2008 · Bioinformatics
Anti-Inflammatory Agent Indomethacin Reduces Invasion and Alters Metabolism in a Human Breast Cancer Cell Line
Ellen Ackerstaff, Barjor Gimi, Dmitri Artemov, Zaver M. Bhujwalla · 2007 · Neoplasia
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Carla A. Borgoño, Tadaaki Kishi, Andreas Scorilas, Nadia Harbeck, Julia Dorn, Barbara Schmalfeldt, Manfred Schmitt, Eleftherios P. Diamandis · 2006 · Clinical Cancer Research
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Jian Li, Xiangjun Hu, Zichuan Xie, Jiajin Li, Chen Lu Huang, Yan Huang · 2024 · Biomedicine & Pharmacotherapy
Expression of macrophage inhibitory cytokine‐1 in prostate cancer bone metastases induces osteoclast activation and weight loss
Savita Wakchoure, Telisha Millender Swain, Teuvo A. Hentunen, Asne R. Bauskin, David Alexander Brown, Samuel N. Breit, Katri S. Vuopala, Kevin W. Harris, Katri S. Selander · 2009 · The Prostate
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Nicole Blanchette-Farra, Daniel Kita, Anna Konstorum, Lia Tesfay, David J. Lemler, Poornima Hegde, Kevin P. Claffey, Frank M. Torti, Suzy V. Torti · 2018 · Oncogene
Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury
Jing Liu, Sanjeev Kumar, Andreas Heinzel, Michael Gao, Jinjin Guo, Gregory F. Alvarado, Roman Reindl‐Schwaighofer, A. Michaela Krautzberger, Pietro E. Cippà, Jill A. McMahon et al. · 2020 · Journal of the American Society of Nephrology
Identification of Lung Cancer Patients by Serum Protein Profiling Using Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Ke-qi Han, Guang Huang, Chunfang Gao, Xiu-li Wang, Bo Ma, Liang-qi Sun, Zhijie Wei · 2008 · American Journal of Clinical Oncology
Placenta: an old organ with new functions
Sara Khorami-Sarvestani, Negar Vanaki, Sorour Shojaeian, Kayhan Zarnani, Allan Stensballe, Mahmood Jeddi‐Tehrani, Amir‐Hassan Zarnani · 2024 · Frontiers in Immunology
Development and Use of Biomarkers in Oncology Drug Development
Eugenia Floyd, Teresa M. McShane · 2004 · Toxicologic Pathology
Bioinformatics Strategies for Translating Genome‐Wide Expression Analyses into Clinically Useful Cancer Markers
Daniel R. Rhodes, Arul M. Chinnaiyan · 2004 · Annals of the New York Academy of Sciences
Macrophage inhibitory cytokine-1 stimulates proliferation of human umbilical vein endothelial cells by up-regulating cyclins D1 and E through the PI3K/Akt-, ERK-, and JNK-dependent AP-1 and E2F activation signaling pathways
Young‐June Jin, Jeong-Hyung Lee, Young-Myeong Kim, Goo Taeg Oh, Hansoo Lee · 2012 · Cellular Signalling
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Yingjuan Qian, Yong-Sam Jung, Xinbin Chen · 2012 · Proceedings of the National Academy of Sciences
Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure
F.M. Verhamme, Leen Seys, Elise G De Smet, Sharen Provoost, Wim Janssens, Dirk Sw Elewaut, Guy Joos, Guy Brusselle, Ken R. Bracke · 2017 · Mucosal Immunology
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Ruth L. Vinall, Clifford G. Tepper, X-B Shi, L A Xue, Regina F. Gandour‐Edwards, Ralph Devere White · 2006 · Oncogene
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Anne-France Le Rolle, Thang Kien Chiu, Michael G. Fara, Jinru Shia, Zhaoshi Zeng, Martin R. Weiser, Philip B. Paty, Vi Kien Chiu · 2015 · Journal of Translational Medicine
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Solomon-Miles Donnelly, E. Paplomata, B.M. Peake, E. Sanabria, Zhuo Chen, Rita Nahta · 2013 · Current Medicinal Chemistry
Emerging Roles of Growth Differentiation Factor 15 in Immunoregulation and Pathogenesis
Jojo Reyes, George S. Yap · 2023 · The Journal of Immunology
Reg IV: A Promising Marker of Hormone Refractory Metastatic Prostate Cancer
Zhennan Gu, Mark A. Rubin, Yu Yang, Samuel E. DePrimo, Hongjuan Zhao, Steve Horvath, James D. Brooks, Massimo F. Loda, Robert Evan Reiter · 2005 · Clinical Cancer Research
An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
Asako Sasahara, Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato et al. · 2017 · Oncotarget
Relaxin becomes upregulated during prostate cancer progression to androgen independence and is negatively regulated by androgens
Vanessa C. Thompson, Tanis G.W. Morris, Dawn R. Cochrane, John Cavanagh, Latif A. Wafa, Tatyana Hamilton, Shunyou Wang, Ladan Fazli, Martin Edwin Gleave, Colleen C. Nelson · 2006 · The Prostate
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Eik Schiegnitz, Peer Wolfgang Kämmerer, Felix P. Koch, Maximilian Krüger, Manfred Berres, Bilal Al‐Nawas · 2012 · Oral Oncology
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Clarence Hale, Murielle M. Véniant · 2020 · Molecular Metabolism
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Victoria Armstrong, Liam W. Fitzgerald, Oliver F. Bathe · 2020 · International Journal of Molecular Sciences
Macrophage Inhibitory Cytokine-1 Regulates Melanoma Vascular Development
Sung Jin Huh, Chin-Ying Chung, Arati K. Sharma, Gavin P. Robertson · 2010 · American Journal Of Pathology
Bioinformatic identification of proteins with tissue-specific expression for biomarker discovery
Ioannis Prassas, Caitlin C Chrystoja, Shalini Makawita, Eleftherios P. Diamandis · 2012 · BMC Medicine
Growth Differentiation Factor-15 (GDF-15) Is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients
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Sheng‐Fan Wang, Shiuan Chen, Ling‐Ming Tseng, Hsin‐Chen Lee · 2020 · Experimental Biology and Medicine
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Ivo M. Meinhold-Heerlein, Dirk Bauerschlag, Yingyao Zhou, Lisa M. Sapinoso, Keith A. Ching, Henry F. Frierson, Karen Bräutigam, Jalid Sehouli, Elmar Stickeler, Dominique Könsgen et al. · 2007 · Clinical Cancer Research
Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma
Meeta P. Pradhan, Akshay Desai, Mathew J. Palakal · 2013 · BMC Systems Biology
Anorexia‐cachexia syndrome in hepatoma tumour‐bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC‐1/GDF15
Tito Borner, Myrtha Arnold, Johan Ruud, Samuel N. Breit, Wolfgang Langhans, Thomas A. Lutz, Anders G. Blomqvist, Thomas Riediger · 2016 · Journal of Cachexia Sarcopenia and Muscle
Differential Secreted Proteome Approach in Murine Model for Candidate Biomarker Discovery in Colon Cancer
Kannan Rangiah, Montri Tippornwong, Vineet Sangar, David Austin, Marie-Pier Tétreault, Anil K. Rustgi, Ian A. Blair, Kenneth H. Yu · 2009 · Journal of Proteome Research
DNA methylation‐mediated silencing of nonsteroidal anti‐inflammatory drug‐activated gene (NAG‐1/GDF15) in glioma cell lines
Mitsutoshi Kadowaki, Hiroki Yoshioka, Hideki Kamitani, Takashi Watanabe, Paul A. Wade, Thomas E. Eling · 2011 · International Journal of Cancer
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Moisés Blanco, Nuria Tarrío, Margarita Reboredo, Mar Haz‐Conde, Jorge García, María Quindós, Angélica Figueroa, Luis Miguel Antón-Aparicio, Lourdes Calvo, Manuel Valladares‐Ayerbes · 2014 · Future Oncology
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Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells
Ke‐Hung Tsui, Ying‐Ling Chang, Tsui‐Hsia Feng, Li‐Chuan Chung, Tzu-Yi Lee, Phei‐Lang Chang, Horng‐Heng Juang · 2012 · Journal of Molecular Endocrinology
Circulating Growth Factor Levels Are Associated with Tumorigenesis in Neurofibromatosis Type 1
George A. Mashour, Pablo Hernáiz Driever, Melanie Hartmann, Stephanie Nicole Drissel, Tingguo Zhang, Bianca Scharf, Ursula Felderhoff‐Müser, Sadatoshi Sakuma, Reinhard Edgar Friedrich, Robert L. Martuza et al. · 2004 · Clinical Cancer Research
Prediction of Body Fluids where Proteins are Secreted into Based on Protein Interaction Network
Le‐Le Hu, Tao Huang, Yu‐Dong Cai, Kuo‐Chen Chou · 2011 · PLoS ONE
Macrophage inhibitory factor 1 acts as a potential biomarker in patients with esophageal squamous cell carcinoma and is a target for antibody‐based therapy
Xiaobing Wang, Xingran Jiang, Xiying Yu, Lin Wang, Shun He, Feiyue Feng, Li‐Ping Guo, Wei Bo Jiang, Shih‐Hsin Lu · 2013 · Cancer Science
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Wyatt Wollmann, Mike L. Goodman, Poornima Bhat‐Nakshatri, Hiromitsu Kishimoto, Robert J. Goulet, Sanjana Mehrotra, Akira Morimiya, Sunil Badve, Harikrishna Nakshatri · 2005 · Carcinogenesis
Tissue microarrays: applications in genomic research
Aprill T. Watanabe, Robert Cornelison, Galen H. Hostetter · 2005 · Expert Review of Molecular Diagnostics
A novel time-course cDNA microarray analysis method identifies genes associated with the development of cisplatin resistance
Martin A. Whiteside, Dung‐Tsa Chen, Renée A. Desmond, Sarki Abba Abdulkadir, Gary L. Johanning · 2004 · Oncogene
Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer
Richard J.E. Skipworth, D A C Deans, Benjamin H. L. Tan, Kathryn Sangster, Simon Paterson‐Brown, David Alexander Brown, M Hunter, Samuel N. Breit, J. A. Ross, Kenneth C. H. Fearon · 2010 · British Journal of Cancer
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Michal Vočka, Daniël Langer, Vladimír Frýba, J Petrtýl, Tomáš Hanuš, Marta Kalousová, Tomáš Zima, Lubos B. Petruzelka · 2018 · Cancer Biomarkers
Protective Effects of Liposomal N-Acetylcysteine against Paraquat-Induced Cytotoxicity and Gene Expression
Panagiotis Mitsopoulos, Zacharias E. Suntres · 2011 · Journal of Toxicology