The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
Open accessAbstract
In addition to neurological deficits, Huntington's disease (HD) patients and transgenic mice expressing mutant human huntingtin exhibit reduced levels of brain-derived neurotrophic factor, hyperglycemia, and tissue wasting. We show that the progression of neuropathological (formation of huntingtin inclusions and apoptotic protease activation), behavioral (motor dysfunction), and metabolic (glucose intolerance and tissue wasting) abnormalities in huntingtin mutant mice, an animal model of HD, are retarded when the mice are maintained on a dietary restriction (DR) feeding regimen resulting in an extension of their life span. DR increases levels of brain-derived neurotrophic factor and the protein chaperone heat-shock protein-70 in the striatum and cortex, which are depleted in HD mice fed a normal diet. The suppression of the pathogenic processes by DR in HD mice suggests that mutant huntingtin promotes neuronal degeneration by impairing cellular stress resistance, and that the body wasting in HD is driven by the neurodegenerative process. Our findings suggest a dietary intervention that may suppress the disease process and increase the life span of humans that carry the mutant huntingtin gene.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“dietary restriction (i.e., the maintenance of a balanced diet) or addition of supplementary substances (e.g., omega-3 fatty acids; resveratrol) can induce an increase in BDNF levels and reduce cognitive impairment in animal models [224–226].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [225]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adams, J., Dinesh, K., Xiong, M., Tarolli, C. G., Sharma, S., Sheth, N., Aranyosi, A. J., Zhu, W. Y., Goldenthal, S. B., Biglan, K., et al. (2017) · Digital Biomarkers · doi:10.1159/000479018 · Cited by 3,190
Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., & Bates, G. P. (1997) · Cell · doi:10.1016/s0092-8674(00)80513-9 · Cited by 2,188
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
Beal, M. F., Kowall, N. W., Ellison, D. W., Mazurek, M. F., Swartz, K. J., & Martin, J. B. (1986) · Nature · doi:10.1038/321168a0 · Cited by 1,287
Andrew, S. E., Goldberg, Y. P., Kremer, B. P. H., Telenius, H., Theilmann, J., Adam, S., Starr, E. M., Squitieri, F., Lin, B., Kalchman, M. A., et al. (1993) · Nature Genetics · doi:10.1038/ng0893-398 · Cited by 1,135
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease
Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., et al. (2001) · Science · doi:10.1126/science.1059581 · Cited by 1,123
Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975
Self-citationDifferential loss of striatal projection neurons in Huntington disease.
Reiner, A., Albin, R. L., Anderson, K. D., D'Amato, C. J., Penney, J. B., & Young, A. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5733 · Cited by 839
BDNF regulates eating behavior and locomotor activity in mice
Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., & Jaenisch, R. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0706 · Cited by 781
Schilling, G. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.3.397 · Cited by 772
Research works printed but not linked: 2
- S E Andrew, Y P Goldberg, B Kremer, H Telenius, J Theilmann, S Adam, E Starr, F Squitieri, B Lin, M A Kalchman, et al. Nat Genet 7, 513–519 (1993).
- A R Heydari, C C Conrad, A Richardson J Nutr 125, 410–418 (1995).
Cited by
Sorted by citations
Items 401–426 of 426
Ricerca, D. I. D., & Orobello, S. (2010)
A study of depression in Huntington's disease
Pang, T. Y. (2008) · Minerva Access (University of Melbourne)
Fasting prevents hypoxia-induced defects of proteostasis in C. elegansPreprint
Iranon, N. N., Jochim, B. E., & Miller, D. L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/278671
Illustrated etiopathogenesis of Huntington's disease
Gupta, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820122-0.00002-9
Anti-Aging Medicine LiteratureWatch
(2003) · Rejuvenation Research · doi:10.1089/109454503769684838
Role of Fine Needle Aspiration Cytology in Evaluation of Cervical Lymphadenopathy
Singh, H., Singh, A. K., & Oberoi, I. S. (2022) · Indian Journal of Forensic Medicine & Toxicology · doi:10.37506/ijfmt.v16i2.17958
Activity-Dependent Induction of Younger Molecular, Cellular and Organism PhenotypesPreprint
Lissek, T. (2022) · Preprints.org · doi:10.20944/preprints202204.0055.v1
Mattson, M. P., & Martin, B. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00104-2
Self-citationLifestyle modifications and nutrition in Alzheimer's disease
Bhatti, G. K., Mishra, J., Sehrawat, A., Sharma, E., Kanozia, R., Navik, U., Reddy, P. H., & Bhatti, J. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89834-8.00049-0
Wibawati, F. H., Girsang, E., Suryaman, R., Yanti, T., & Aprianty, S. T. (2022) · Indian Journal of Public Health Research & Development · doi:10.37506/ijphrd.v13i2.17931
Zhou, L., Bao, F., Zheng, J., Ding, Y., Xiao, J., Zhang, J., Qin, Y., Yang, L., Wu, Y., Meng, Q., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.14.599123
Wells, R. G., Neilson, L. E., & Hiller, A. (2025) · Nutrition and Health · doi:10.1177/02601060251378785
“Speci fi cally, subtypes such as alternate-day fasting and daily time-restricted eating have both displayed neuroprotective and disease-modifying effects in animal models of HD (Duan et al., 2003; Ehrnhoefer et al., 2018; Wang et al., 2018; Wells et al., 2024).”
Oruç, D., & Işık, S. (2025) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.1571616
Souza, G. N. (2012) · Lume (Universidade Federal do Rio Grande do Sul)
Additional file 1 of The involvement of neuroimmune cells in adipose innervation
Blaszkiewicz, M., Wood, E., Koizar, S., Willows, J., Anderson, R., Tseng, Y.-H., Godwin, J. W., & Townsend, K. L. (2020) · Figshare · doi:10.6084/m9.figshare.13357478
Additional file 2 of The involvement of neuroimmune cells in adipose innervation
Blaszkiewicz, M., Wood, E., Koizar, S., Willows, J., Anderson, R., Tseng, Y.-H., Godwin, J. W., & Townsend, K. L. (2020) · Figshare · doi:10.6084/m9.figshare.13357487
Ibargüen-Vargas, Y. (2008) · theses.fr (ABES) · doi:10.70675/2d73c017z46fcz4c35z8397zb504072e069a
Gil‐Salcedo, A., Massart, R., Youssov, K., Morgado, G., & Bachoud‐Lévi, A. (2026) · Journal of Neurology · doi:10.1007/s00415-026-13717-0
Effect of post-ischemic caloric restriction on cell death and functional recovery
McEwen, B. R. (2009) · University Library - University of Saskatchewan (University of Saskatchewan)
Liu, B., Zhang, Y., Deng, W., Zhou, Y., Cao, Y., Xiong, L., Shen, R., Lee, S. M.-Y., Bian, J., & Bian, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1731416
Effects of time-restricted eating in early-stage Huntington’s disease: a pilot study
Wells, R. G., Neilson, L. E., McHill, A. W., Gray, N. E., Quinn, J. F., & Hiller, A. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01612-x
“…3 months of alternate-day fasting in HD transgenic mice was found to mitigate tissue wasting and weight loss relative to animals fed ad libitum 11 , an effect that may reflect a fasting-induced adaptive increase in growth hormone secretion that is thought to exist to preserve skeletal muscle…”
Caloric restriction’s molecular pathways: Unlocking neuroprotection in neurodegenerative diseases
MITKARI, M., Pawar, A., Hulwale, A., Shelke, V., Vyavahare, S., Doke, R. R., & Singh, S. (2026) · PharmaNutrition · doi:10.1016/j.phanu.2026.100543
Behrends, C. (2007) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.6654
Metadata
- Authors
- Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P.
- Affiliations
- Johns Hopkins University (US)
- National Institutes of Health (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2003-02-14
- Volume
- 100
- Issue
- 5
- Pages
- 2911-2916
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC151440
- OpenAlex
- W1997887740
- Cited by
- 428
- References
- 59
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 14 · 2023: 8 · 2022: 17 · 2021: 13 · 2020: 18 · 2019: 19 · 2018: 18 · 2017: 22 · 2016: 13 · 2015: 18 · 2014: 26 · 2013: 18 · 2012: 16
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
- Keywords
- Huntington's disease, dietary restriction, brain-derived neurotrophic factor, HSP70, impaired glucose tolerance, hyperglycemia, tissue wasting, motor impairment, apoptosis, neurodegeneration, cellular stress resistance, lifespan extension, striatum, cortex
- MeSH terms
- Huntingtin Protein, Animals, Behavior, Animal, Blood Glucose, Brain, Cell Survival, Enzyme Activation, Enzyme-Linked Immunosorbent Assay, Glucose, Insulin, Male, Mice, Transgenic, Mutation, Nerve Tissue Proteins, Nuclear Proteins, Time Factors, Immunoblotting, Up-Regulation, Disease Progression, Brain-Derived Neurotrophic Factor, Neurodegenerative Diseases, Caspases, Leptin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
