BDNF regulates eating behavior and locomotor activity in mice
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Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development. Ablation of this gene in mice leads to death shortly after birth, and abnormalities have been found in both the peripheral and central nervous systems. BDNF and its tyrosine kinase receptor, TrkB, are expressed in hypothalamic nuclei associated with satiety and locomotor activity. In heterozygous mice, BDNF gene expression is reduced and we find that all heterozygous mice exhibit abnormalities in eating behavior or locomotor activity. We also observe this phenotype in independently derived inbred and hybrid BDNF mutant strains. Infusion with BDNF or NT4/5 can transiently reverse the eating behavior and obesity. Thus, we identify a novel non-neurotrophic function for neurotrophins and indicate a role in behavior that is remarkably sensitive to alterations in BDNF activity.
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rs10835211 (menarche P=9.4×10−6) is near BDNF, a BMI locus implicated in eating behavior and body weight regulation.
“rs10835211 (menarche P-value=9.4×10−6) is near BDNF, which is a BMI locus and is implicated in eating behavior and body weight regulation27,28.”
From Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies (2010) · cites this paper as [27]
BDNF affects the regulation of feeding and energy metabolism.
“BDNF is known to affect the regulation of feeding and energy metabolism [218–221].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [220]
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Attention-deficit/hyperactivity disorder (ADHD) and binge eating.
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Mice with altered BDNF signaling as models for mood disorders and antidepressant effects
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- Authors
- Kernie, S. G., Liebl, D. J., & Parada, L. F.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Parada, Luis F.
- Venue
- The EMBO Journal
- Published
- 2000-03-15
- Volume
- 19
- Issue
- 6
- Pages
- 1290-1300
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC305670
- OpenAlex
- W1979722180
- Cited by
- 806
- References
- 63
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 18 · 2023: 31 · 2022: 31 · 2021: 31 · 2020: 31 · 2019: 25 · 2018: 33 · 2017: 27 · 2016: 39 · 2015: 49 · 2014: 37 · 2013: 51 · 2012: 44
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns033199-04, RR02584)
- National Institute of Neurological Disorders and Stroke (R01 NS33199-05, R37NS033199)
- National Center for Research Resources (P41-RR-02584, P41RR002584)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, TrkB receptor, dietary habits, locomotor activity, hypothalamus, satiety, obesity, neurotrophins, heterozygous mice
- MeSH terms
- Cocaine- and Amphetamine-Regulated Transcript Protein, Animals, Appetite, Body Weight, Carrier Proteins, Feeding Behavior, Female, Heterozygote, Humans, Hypothalamus, Insulin, Male, Mice, Inbred Strains, Motor Activity, Nerve Tissue Proteins, Neuropeptide Y, Obesity, Receptors, Cell Surface, RNA, Messenger, Adipocytes, Mice, Knockout, Brain-Derived Neurotrophic Factor, Leptin, Receptor, trkB, Mice, Receptors, Leptin
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