The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Pannexin 1 in erythrocytes: Function without a gap
Abstract
ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress. In the absence of vesicles, the release has to be through channels. Erythrocytes do not form gap junctions. Yet, here we show with immunohistochemical and electrophysiological data that erythrocytes express the gap junction protein pannexin 1. This protein, in addition to forming gap junction channels in paired oocytes, can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Consistent with a role of pannexin 1 as an ATP release channel, ATP release by erythrocytes was attenuated by the gap junction blocker carbenoxolone. Furthermore, under conditions of ATP release, erythrocytes took up fluorescent tracer molecules permeant to gap junction channels.
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Cites
Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels
Stout, C. E., Costantin, J. L., Naus, C. C. G., & Charles, A. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109902200 · Cited by 865
Pannexin membrane channels are mechanosensitive conduits for ATP
Bao, L., Locovei, S., & Dahl, G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.009 · Cited by 802
Self-citationCellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
Burnstock, G., & Knight, G. E. (2004) · International Review of Cytology · doi:10.1016/s0074-7696(04)40002-3 · Cited by 795
Pannexins, a family of gap junction proteins expressed in brain
Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A., & Monyer, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233464100 · Cited by 774
Connexins regulate calcium signaling by controlling ATP release
Cotrina, M. L., Lin, J. H.-C., Alves-Rodrigues, A., Liu, S., Li, J., Azmi-Ghadimi, H., Kang, J., Naus, C. C. G., & Nedergaard, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15735 · Cited by 772
Nucleotide receptors: an emerging family of regulatory molecules in blood cells
Di Virgilio, F., Chiozzi, P., Ferrari, D., Falzoni, S., Sanz, J. M., Morelli, A., Torboli, M., Bolognesi, G., & Baricordi, O. R. (2001) · Blood · doi:10.1182/blood.v97.3.587 · Cited by 703
Paul, D. L., Ebihara, L., Takemoto, L. J., Swenson, K. I., & Goodenough, D. A. (1991) · The Journal of cell biology · doi:10.1083/jcb.115.4.1077 · Cited by 606
A ubiquitous family of putative gap junction molecules
Panchina, Y., Kelmanson, I., Matz, M., Lukyanov, K., Usman, N., & Lukyanov, S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00576-5 · Cited by 562
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
Locovei, S., Wang, J., & Dahl, G. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.004 · Cited by 520
Self-citationP2X7Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+Signaling
Suadicani, S. O., Brosnan, C. F., & Scemes, E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3902-05.2006 · Cited by 512
Cited by
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153
Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis
Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F. J., Marchand-Adam, S., Crestani, B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0359oc · Cited by 397
Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels”
Iglesias, R., Dahl, G., Qiu, F., Spray, D. C., & Scemes, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.6062-08.2009 · Cited by 353
Self-citationExtracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors
Kurashima, Y., Amiya, T., Nochi, T., Fujisawa, K., Haraguchi, T., Iba, H., Tsutsui, H., Sato, S., Nakajima, S., Iijima, H., et al. (2012) · Nature Communications · doi:10.1038/ncomms2023 · Cited by 286
Metadata
- Authors
- Locovei, S., Bao, L., & Dahl, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-05-16
- Volume
- 103
- Issue
- 20
- Pages
- 7655-7659
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077857158
- Cited by
- 508
- References
- 27
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- closed
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