The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels”
Open accessAbstract
Purinergic signaling plays distinct and important roles in the CNS, including the transmission of calcium signals between astrocytes. Gap junction hemichannels are among the mechanisms proposed by which astrocytes might release ATP; however, whether the gap junction protein connexin43 (Cx43) forms these “hemichannels” remains controversial. Recently, a new group of proteins, the pannexins, have been shown to form nonselective, high-conductance plasmalemmal channels permeable to ATP, thereby offering an alternative for the hemichannel protein. Here, we provide strong evidence that, in cultured astrocytes, pannexin1 (Panx1) but not Cx43 forms hemichannels. Electrophysiological and fluorescence microscope recordings performed in wild-type and Cx43-null astrocytes did not reveal any differences in hemichannel activity, which was mostly eliminated by treating Cx43-null astrocytes with Panx1-short interfering RNA [Panx1-knockdown (Panx1-KD)]. Moreover, quantification of the amount of ATP released from wild-type, Cx43-null, and Panx1-KD astrocytes indicates that downregulation of Panx1, but not of Cx43, prevented ATP release from these cells.
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Cites
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
Pelegrin, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,431
Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels
Stout, C. E., Costantin, J. L., Naus, C. C. G., & Charles, A. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109902200 · Cited by 865
Pannexin membrane channels are mechanosensitive conduits for ATP
Bao, L., Locovei, S., & Dahl, G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.009 · Cited by 802
Self-citationPannexins, a family of gap junction proteins expressed in brain
Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A., & Monyer, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233464100 · Cited by 774
Connexins regulate calcium signaling by controlling ATP release
Cotrina, M. L., Lin, J. H.-C., Alves-Rodrigues, A., Liu, S., Li, J., Azmi-Ghadimi, H., Kang, J., Naus, C. C. G., & Nedergaard, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15735 · Cited by 772
Dave, K. A., & White, S. W. (2002) · World Highways/Routes du Monde · Cited by 765
Functional Hemichannels in Astrocytes: A Novel Mechanism of Glutamate Release
Ye, Z.-C., Wyeth, M. S., Baltan-Tekkok, S., & Ransom, B. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03588.2003 · Cited by 704
Contreras, J. E., Sánchez, H. A., Eugenín, E. A., Speidel, D., Theis, M., Willecke, K., Bukauskas, F. F., Bennett, M. V. L., & Sáez, J. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012589799 · Cited by 540
The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds
Huang, Y.-J., Maruyama, Y., Dvoryanchikov, G., Pereira, E., Chaudhari, N., & Roper, S. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611280104 · Cited by 532
Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
Locovei, S., Wang, J., & Dahl, G. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.004 · Cited by 520
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Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Osteocytes: master orchestrators of bone
Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9790-y · Cited by 514
Extracellular ATP Is a Danger Signal Activating P2X7 Receptor in Lung Inflammation and Fibrosis
Riteau, N., Gasse, P., Fauconnier, L., Gombault, A., Couegnat, M., Fick, L., Kanellopoulos, J., Quesniaux, V. F. J., Marchand-Adam, S., Crestani, B., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201003-0359oc · Cited by 397
Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation
Qu, Y., Misaghi, S., Newton, K., Gilmour, L. L., Louie, S., Cupp, J. E., Dubyak, G. R., Hackos, D., & Dixit, V. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100478 · Cited by 363
Fontainhas, A. M., Wang, M., Liang, K. J., Chen, S., Mettu, P., Damani, M., Fariss, R. N., Li, W., & Wong, W. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015973 · Cited by 334
Metadata
- Authors
- Iglesias, R., Dahl, G., Qiu, F., Spray, D. C., & Scemes, E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2009-05-27
- Volume
- 29
- Issue
- 21
- Pages
- 7092-7097
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2050886623
- Cited by
- 353
- References
- 32
- FWCI
- 22.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Iglesias, R., Dahl, G., Qiu, F., Spray, D. C., & Scemes, E. (2009). Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels”. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.6062-08.2009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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