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Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8
Abstract
Mammalian oogenesis requires oocyte-specific transcriptional regulators. The full complement of oocyte-specific transcription factors is unknown. Here, we describe the finding that Sohlh1 , a spermatogenesis and oogenesis basic helix–loop–helix transcription factor in females, is preferentially expressed in oocytes and required for oogenesis. Sohlh1 disruption perturbs follicular formation in part by causing down-regulation of two genes that are known to disrupt folliculogenesis: newborn ovary homeobox gene ( Nobox ) and factor in the germ-line alpha ( Figla ). In addition, we show that Lhx8 is downstream of Sohlh1 and critical in fertility. Thus, Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis.
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Cited by
Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
White, Y. A. R., Woods, D. C., Takai, Y., Ishihara, O., Seki, H., & Tilly, J. L. (2012) · Nature Medicine · doi:10.1038/nm.2669 · Cited by 719
The ovary: basic biology and clinical implications
Richards, J. S., & Pangas, S. A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41350 · Cited by 561
Self-citationGenetics of primary ovarian insufficiency: new developments and opportunities
Qin, Y., Jiao, X., Simpson, J. L., & Chen, Z.-J. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv036 · Cited by 554
Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles
Adhikari, D., & Liu, K. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0048 · Cited by 481
Zhang, H., & Liu, K. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv037 · Cited by 274
Metadata
- Authors
- Pangas, S. A., Choi, Y., Ballow, D. J., Zhao, Y., Westphal, H., Matzuk, M. M., & Rajkovic, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-05-23
- Volume
- 103
- Issue
- 21
- Pages
- 8090-8095
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2055994125
- Cited by
- 280
- References
- 0
- FWCI
- 12.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pangas, S. A., Choi, Y., Ballow, D. J., Zhao, Y., Westphal, H., Matzuk, M. M., & Rajkovic, A. (2006). Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0601083103
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