The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging
Open accessAbstract
Despite functional evidence for disulfide bond-reducing activity in endosomal compartments, the mechanistic details pertaining to such process (e.g., kinetics and sites of disulfide reduction) remain largely controversial. To address these questions directly, we have synthesized a previously uncharacterized fluorescent folate conjugate, folate-(BODIPY FL)-SS-rhodamine (folate-FRET), that changes fluorescence from red to green upon disulfide bond reduction. Using this construct, we have observed that disulfide reduction: ( i ) occurs with a half-time of 6 h after folate-FRET endocytosis, ( ii ) begins in endosomes and does not depend significantly on redox machinery located on the cell surface or within the lysosome or the Golgi apparatus, ( iii ) occurs independently of endocytic vesicle trafficking along microtubules, and ( iv ) yields products that are subsequently sorted into distinct endosomes and trafficked in different directions. Finally, colocalization of folate and transferrin receptors suggest that conclusions derived from this study may apply to other endocytic pathways.
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Metadata
- Authors
- Yang, J., Chen, H., Vlahov, I. R., Cheng, J.-X., & Low, P. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-09-12
- Volume
- 103
- Issue
- 37
- Pages
- 13872-13877
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1988959629
- Cited by
- 318
- References
- 42
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- green
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