Cited by 708Characterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug DeliveryMagnetic Properties and Synthesis of Ferrites

Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications

Gupta, Ajay Kumar, Naregalkar, Rohan R, Vaidya, Vikas Deep, Gupta, Mona·2007·Nanomedicine

Abstract

Magnetic nanoparticles with appropriate surface coatings are increasingly being used clinically for various biomedical applications, such as magnetic resonance imaging, hyperthermia, drug delivery, tissue repair, cell and tissue targeting and transfection. This is because of the nontoxicity and biocompatibility demand that mainly iron oxide-based materials are predominantly used, despite some attempts to develop 'more magnetic nanomaterials' based on cobalt, nickel, gadolinium and other compounds. For all these applications, the material used for surface coating of the magnetic particles must not only be nontoxic and biocompatible but also allow a targetable delivery with particle localization in a specific area. Magnetic nanoparticles can bind to drugs and an external magnetic field can be applied to trap them in the target site. By attaching the targeting molecules, such as proteins or antibodies, at particles surfaces, the latter may be directed to any cell, tissue or tumor in the body. In this review, different polymers/molecules that can be used for nanoparticle coating to stabilize the suspensions of magnetic nanoparticles under in vitro and in vivo situations are discussed. Some selected proteins/targeting ligands that could be used for derivatizing magnetic nanoparticles are also explored. We have reviewed the various biomedical applications with some of the most recent uses of magnetic nanoparticles for early detection of cancer, diabetes and atherosclerosis.

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Registry

Crossref · 10.2217/17435889.2.1.23

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87 of 87 references verified0 citation errors · 0 not checkable

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  • SPION have high magnetic moments when exposed to an external magnetic field, and no remaining magnetic moment when the magnetic field is turned off.

    “SPION have high magnetic moments when exposed to an external magnetic field, and no remaining magnetic moment when the magnetic field is turned off [21].”

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Authors
Gupta, A. K., Naregalkar, R. R., Vaidya, V. D., & Gupta, M.
Affiliations
Laboratory for Nanoparticle Research, Formulation & Development Department, Torrent Research Centre, TPL, Village Bhat, Dist. Gandhinagar – 382 428, Gujarat, India.
Venue
Nanomedicine
Published
2007-02
Volume
2
Issue
1
Pages
23-39
ISSN
  • 1743-5889 (ISSN-L)
  • 1748-6963
OpenAlex
W2141214816
Cited by
708
References
87
Citations by year
2026: 13 · 2025: 23 · 2024: 28 · 2023: 25 · 2022: 36 · 2021: 51 · 2020: 33 · 2019: 44 · 2018: 37 · 2017: 36 · 2016: 33 · 2015: 49 · 2014: 49 · 2013: 46 · 2012: 51
FWCI
2.88
Type
journal article
Language
en
Open access
closed
Locations
  • Nanomedicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
Keywords
magnetic iron oxide nanoparticles, surface coating, surface engineering, magnetic resonance imaging, hyperthermia, drug delivery, targeted drug delivery, transfection, biocompatibility, nanoparticle stabilization, targeting ligands, immunoglobulins, proteins, cancer detection, diabetes detection, atherosclerosis detection
MeSH terms
Biomedical Engineering, Contrast Media, Ferric Compounds, Forecasting, Image Enhancement, Magnetic Resonance Imaging, Magnetics, Surface Properties, Transfection, Molecular Probe Techniques, Drug Delivery Systems, Nanomedicine, Nanoparticles

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