Toll-like receptor 4 plays a crucial role in the immune–adrenal response to systemic inflammatory response syndrome

Zacharowski, Kai; Zacharowski, Paula A.; Koch, Alexander; Baban, Aida; Tran, Nguyen; Berkels, Reinhard; Papewalis, Claudia; Schulze-Osthoff, Klaus; Knuefermann, Pascal; Zähringer, Ulrich; Schumann, Ralf R.; Rettori, Valeria; McCann, Samuel M.; Bornstein, Stefan R.

doi:10.1073/pnas.0601527103

Toll-like receptor 4 plays a crucial role in the immune–adrenal response to systemic inflammatory response syndrome

Sepsis and septic shock are leading killers in the noncoronary intensive care unit, and they remain worldwide health concerns. The initial host defense against bacterial infections involves Toll-like receptors (TLRs), which detect and respond to microbial ligands. In addition, a coordinated respo…