The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Positive selection driving diversification in plant secondary metabolism
Open accessAbstract
In Arabidopsis thaliana and related plants, glucosinolates are a major component in the blend of secondary metabolites and contribute to resistance against herbivorous insects. Methylthioalkylmalate synthases (MAM) encoded at the MAM gene cluster control an early step in the biosynthesis of glucosinolates and, therefore, are central to the diversification of glucosinolate metabolism. We sequenced bacterial artificial chromosomes containing the MAM cluster from several Arabidopsis relatives, conducted enzyme assays with heterologously expressed MAM genes, and analyzed MAM nucleotide variation patterns. Our results show that gene duplication, neofunctionalization, and positive selection provide the mechanism for biochemical adaptation in plant defense. These processes occur repeatedly in the history of the MAM gene family, indicating their fundamental importance for the evolution of plant metabolic diversity both within and among species.
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Cites
The Evolutionary Fate and Consequences of Duplicate Genes
Lynch, M., & Conery, J. S. (2000) · Science · doi:10.1126/science.290.5494.1151 · Cited by 4,988
Yang, Z. (1994) · Journal of Molecular Evolution · doi:10.1007/bf00160154 · Cited by 2,960
Yang, Z., & Nielsen, R. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004148 · Cited by 1,374
Cited by
The Brassica oleracea genome reveals the asymmetrical evolution of polyploid genomes
Liu, S., Liu, Y., Yang, X., Tong, C., Edwards, D., Parkin, I. A. P., Zhao, M., Ma, J., Yu, J., Huang, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms4930 · Cited by 1,161
Biosynthesis of glucosinolates – gene discovery and beyond
Sønderby, I. E., Geu-Flores, F., & Halkier, B. A. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.02.005 · Cited by 956
Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
Hanikenne, M., Talke, I. N., Haydon, M. J., Lanz, C., Nolte, A., Motte, P., Kroymann, J., Weigel, D., & Krämer, U. (2008) · Nature · doi:10.1038/nature06877 · Cited by 812
Self-citationMacroevolution and the biological diversity of plants and herbivores
Futuyma, D. J., & Agrawal, A. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904106106 · Cited by 632
Explaining intraspecific diversity in plant secondary metabolites in an ecological context
Moore, B. D., Andrew, R. L., Külheim, C., & Foley, W. J. (2014) · New Phytologist · doi:10.1111/nph.12526 · Cited by 533
Metadata
- Authors
- Benderoth, M., Textor, S., Windsor, A. J., Mitchell-Olds, T., Gershenzon, J., & Kroymann, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-06-13
- Volume
- 103
- Issue
- 24
- Pages
- 9118-9123
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2133174791
- Cited by
- 227
- References
- 3
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Benderoth, M., Textor, S., Windsor, A. J., Mitchell-Olds, T., Gershenzon, J., & Kroymann, J. (2006). Positive selection driving diversification in plant secondary metabolism. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0601738103
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