The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Neurons produce type I interferon during viral encephalitis
Open accessAbstract
Type I interferons, also referred to as IFN-α/β, form the first line of defense against viral infections. Major IFN-α/β producers in the periphery are the plasmacytoid dendritic cells (pDCs). Constitutive expression of the IFN regulatory factor (IRF)-7 enables pDCs to rapidly synthesize large amounts of IFN-α/β after viral infection. In the central nervous system (CNS), pDCs are considered to be absent from the parenchyma, and little is known about the cells producing IFN-α/β. The study presented here aimed to identify the cells producing IFN-α/β in the CNS in vivo after infection by neurotropic viruses such as Theiler's virus and La Crosse virus. No cells with high constitutive expression of IRF-7 were detected in the CNS of uninfected mice, suggesting the absence of cells equivalent to pDCs. Upon viral infection, IFN-β and some subtypes of IFN-α, but not IFN-ε or IFN-κ, were transcriptionally up-regulated. IFN-α/β was predominantly produced by scattered parenchymal cells and much less by cells of inflammatory foci. Interestingly, in addition to some macrophages and ependymal cells, neurons turned out to be important producers of both IFN-α and IFN-β. However, only 3% of the infected neurons produced IFN-α/β, suggesting that some restriction to IFN-α/β production existed in these cells. All CNS cell types analyzed, including neurons, were able to respond to type I IFN by producing Mx or IRF-7. Our data show that, in vivo , neurons take an active part to the antiviral defense by being both IFN-α/β producers and responders.
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“Type I Interferon responses in the brain are classically attributed to viral infections that can produce M1 activation states in microglia26.”
From Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism (2014) · cites this paper as [26]
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Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
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Self-citationGupta, S., Ellis, S. E., Ashar, F. N., Moes, A., Bader, J. S., Zhan, J., West, A. B., & Arking, D. E. (2014) · Nature Communications · doi:10.1038/ncomms6748 · Cited by 504
“Type I Interferon responses in the brain are classically attributed to viral infections that can produce M1 activation states in microglia 26 .”
Ependymal cells: biology and pathology
Bigio, M. R. D. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0624-y · Cited by 401
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Metadata
- Authors
- Delhaye, S., Paul, S., Blakqori, G., Minet, M., Weber, F., Staeheli, P., & Michiels, T.
- Affiliations
- de Duve Institute (BE)
- University of Freiburg (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-05-16
- Volume
- 103
- Issue
- 20
- Pages
- 7835-7840
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1458506
- OpenAlex
- W2037012882
- Cited by
- 266
- References
- 36
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 14 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 12 · 2016: 13 · 2015: 9 · 2014: 16 · 2013: 20 · 2012: 17
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- Funders
- Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
- Deutsche Forschungsgemeinschaft
- Fonds De La Recherche Scientifique - FNRS
- Fondation Charcot
- Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- type I interferon, neurons, viral encephalitis, neurotropic viruses, Theiler's virus, La Crosse virus, IRF7, plasmacytoid dendritic cells, antiviral defense, Mx protein, central nervous system, macrophages, ependymal cells
- MeSH terms
- Animals, Central Nervous System, Epithelial Cells, Female, Humans, Macrophages, Mice, Inbred Strains, Neurons, Interferon-alpha, Interferon-beta, Encephalitis, Viral, Protein Isoforms, Interferon Regulatory Factor-7, Mice
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