The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Prenatal exposure to ultrasound waves impacts neuronal migration in mice
Open accessAbstract
Neurons of the cerebral neocortex in mammals, including humans, are generated during fetal life in the proliferative zones and then migrate to their final destinations by following an inside-to-outside sequence. The present study examined the effect of ultrasound waves (USW) on neuronal position within the embryonic cerebral cortex in mice. We used a single BrdU injection to label neurons generated at embryonic day 16 and destined for the superficial cortical layers. Our analysis of over 335 animals reveals that, when exposed to USW for a total of 30 min or longer during the period of their migration, a small but statistically significant number of neurons fail to acquire their proper position and remain scattered within inappropriate cortical layers and/or in the subjacent white matter. The magnitude of dispersion of labeled neurons was variable but systematically increased with duration of exposure to USW. These results call for a further investigation in larger and slower-developing brains of non-human primates and continued scrutiny of unnecessarily long prenatal ultrasound exposure.
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“Multiple fetuses per pregnancy, intrauterine growth restriction (IUGR, due to placental failure other than by causes described above), X-ray, UV, nuclear or cosmic radiation, (ultra)sound as well as high temperature, preterm birth or hypoxia whether or not by traumatic causes can pose serious threats to proper corticogenesis as well [349–356].”
From Development of prefrontal cortex (2022) · cites this paper as [354]
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Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits
Tufail, Y., Matyushov, A. D., Baldwin, N. G., Tauchmann, M. L., Georges, J., Yoshihiro, A., Tillery, S. I. H., & Tyler, W. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.008 · Cited by 958
Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound
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Metadata
- Authors
- Ang, E. S. B. C., Gluncic, V., Duque, A., Schafer, M. E., & Rakic, P.
- Affiliations
- Yale University (US)
- *Department of Neurobiology and Kavli Institute for Neuroscience, Yale Medical School, Sterling Hall of Medicine, Room C-318, 333 Cedar Street, New Haven, CT 06510; and
- Sonic Tech, Inc., 23 Brookline Court, Ambler, PA 19002
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-08-22
- Volume
- 103
- Issue
- 34
- Pages
- 12903-12910
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2049591511
- Cited by
- 265
- References
- 51
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 10 · 2018: 7 · 2017: 66 · 2016: 16 · 2015: 11 · 2014: 13 · 2013: 13 · 2012: 10
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Keywords
- prenatal ultrasound exposure, neuronal migration, cerebral cortex, cortical lamination, BrdU labeling, white matter, embryonic brain development, mouse embryo
- MeSH terms
- Animals, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Female, Neurons, Pregnancy, Ultrasonography, Mice
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