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Deterministic hydrodynamics: Taking blood apart
Open accessAbstract
We show the fractionation of whole blood components and isolation of blood plasma with no dilution by using a continuous-flow deterministic array that separates blood components by their hydrodynamic size, independent of their mass. We use the technology we developed of deterministic arrays which separate white blood cells, red blood cells, and platelets from blood plasma at flow velocities of 1,000 μm/sec and volume rates up to 1 μl/min. We verified by flow cytometry that an array using focused injection removed 100% of the lymphocytes and monocytes from the main red blood cell and platelet stream. Using a second design, we demonstrated the separation of blood plasma from the blood cells (white, red, and platelets) with virtually no dilution of the plasma and no cellular contamination of the plasma.
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Citations
Cited by
Single-cell RNA-seq: advances and future challenges
Saliba, A.-E., Westermann, A. J., Gorski, S. A., & Vogel, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku555 · Cited by 847
“Recent advances in engineering have allowed researchers to go beyond using molecular markers by specifying cells based on physiological and biophysical features such as cell size (69), deformation (70,71), and electric (72) or magnetic properties (73).”
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Hydrodynamic mechanisms of cell and particle trapping in microfluidics
Karimi, A., Yazdi, S., & Ardekani, A. M. (2013) · Biomicrofluidics · doi:10.1063/1.4799787 · Cited by 384
High-throughput size-based rare cell enrichment using microscale vortices
Hur, S. C., Mach, A. J., & Di Carlo, D. (2011) · Biomicrofluidics · doi:10.1063/1.3576780 · Cited by 317
Droplet-based single cell RNAseq tools: a practical guide
Salomon, R., Kaczorowski, D., Valdes-Mora, F., Nordon, R. E., Neild, A., Farbehi, N., Bartonicek, N., & Gallego-Ortega, D. (2019) · Lab on a Chip · doi:10.1039/c8lc01239c · Cited by 109
Metadata
- Authors
- Davis, J. A., Inglis, D. W., Morton, K. J., Lawrence, D. A., Huang, L. R., Chou, S. Y., Sturm, J. C., & Austin, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-10-03
- Volume
- 103
- Issue
- 40
- Pages
- 14779-14784
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102153483
- Cited by
- 622
- References
- 0
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Davis, J. A., Inglis, D. W., Morton, K. J., Lawrence, D. A., Huang, L. R., Chou, S. Y., Sturm, J. C., & Austin, R. H. (2006). Deterministic hydrodynamics: Taking blood apart. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0605967103
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