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Cited by 396

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation

Open access
Cropley, Jennifer E., Suter, Catherine M., Beckman, Kenneth B., Martin, David I. K.·2006·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0607090103
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Abstract

Environmental effects on phenotype can be mediated by epigenetic modifications. The epigenetic state of the murine A vy allele is highly variable, and determines phenotypic effects that vary in a mosaic spectrum that can be shifted by in utero exposure to methyl donor supplementation. We have asked if methyl donor supplementation affects the germ-line epigenetic state of the A vy allele. We find that the somatic epigenetic state of A vy is affected by in utero methyl donor supplementation only when the allele is paternally contributed. Exposure to methyl donor supplementation during midgestation shifts A vy phenotypes not only in the mice exposed as fetuses, but in their offspring. This finding indicates that methyl donors can change the epigenetic state of the A vy allele in the germ line, and that the altered state is retained through the epigenetic resetting that takes place in gametogenesis and embryogenesis. Thus a mother's diet may have an enduring influence on succeeding generations, independent of later changes in diet. Although other reports have suggested such heritable epigenetic changes, this study demonstrates that a specific mammalian gene can be subjected to germ-line epigenetic change.

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Metadata

Authors
Cropley, J. E., Suter, C. M., Beckman, K. B., & Martin, D. I. K.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2006-11-14
Volume
103
Issue
46
Pages
17308-17312
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0607090103
OpenAlex
W2143120330
Cited by
396
References
27
FWCI
11.30
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. https://app.cochat.ai/papers/10.1073/pnas.0607090103
The paper
Cropley, J. E., Suter, C. M., Beckman, K. B., & Martin, D. I. K. (2006). Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0607090103

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.