The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone
Open accessAbstract
Indian hedgehog (Ihh) is essential for chondrocyte and osteoblast proliferation/differentiation during prenatal endochondral bone formation. The early lethality of various Ihh -ablated mutant mice, however, prevented further analysis of its role in postnatal bone growth and development. In this study, we describe the generation and characterization of a mouse model in which the Ihh gene was successfully ablated from postnatal chondrocytes in a temporal/spatial-specific manner; postnatal deletion of Ihh resulted in loss of columnar structure, premature vascular invasion, and formation of ectopic hypertrophic chondrocytes in the growth plate. Furthermore, destruction of the articular surface in long bones and premature fusion of growth plates of various endochondral bones was evident, resulting in dwarfism in mutant mice. More importantly, these mutant mice exhibited continuous loss of trabecular bone over time, which was accompanied by reduced Wnt signaling in the osteoblastic cells. These results demonstrate, for the first time, that postnatal chondrocyte-derived Ihh is essential for maintaining the growth plate and articular surface and is required for sustaining trabecular bone and skeletal growth.
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Cites
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Toward a molecular understanding of skeletal development
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Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton
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Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Genetic Control of Bone Formation
Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667
The Hedgehog's tale: developing strategies for targeting cancer
Ng, J. M. Y., & Curran, T. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3079 · Cited by 398
Aghajanian, P., & Mohan, S. (2018) · Bone Research · doi:10.1038/s41413-018-0021-z · Cited by 284
Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances
Xue, C., Chu, Q., Shi, Q., Zeng, Y., Lu, J., & Li, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02142-w · Cited by 281
Metadata
- Authors
- Maeda, Y., Nakamura, E., Nguyen, M.-T., Suva, L. J., Swain, F. L., Razzaque, M. S., Mackem, S., & Lanske, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-04-10
- Volume
- 104
- Issue
- 15
- Pages
- 6382-6387
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1993851741
- Cited by
- 268
- References
- 24
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Maeda, Y., Nakamura, E., Nguyen, M.-T., Suva, L. J., Swain, F. L., Razzaque, M. S., Mackem, S., & Lanske, B. (2007). Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0608449104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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