The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI
Open accessAbstract
Noninvasive monitoring of stem cells, using high-resolution molecular imaging, will be instrumental to improve clinical neural transplantation strategies. We show that labeling of human central nervous system stem cells grown as neurospheres with magnetic nanoparticles does not adversely affect survival, migration, and differentiation or alter neuronal electrophysiological characteristics. Using MRI, we show that human central nervous system stem cells transplanted either to the neonatal, the adult, or the injured rodent brain respond to cues characteristic for the ambient microenvironment resulting in distinct migration patterns. Nanoparticle-labeled human central nervous system stem cells survive long-term and differentiate in a site-specific manner identical to that seen for transplants of unlabeled cells. We also demonstrate the impact of graft location on cell migration and describe magnetic resonance characteristics of graft cell death and subsequent clearance. Knowledge of migration patterns and implementation of noninvasive stem cell tracking might help to improve the design of future clinical neural stem cell transplantation.
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Cites
Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α
Stellwagen, D., Beattie, E. C., Seo, J. Y., & Malenka, R. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-04.2005 · Cited by 985
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Cited by
Biological applications of magnetic nanoparticles
Colombo, M., Carregal-Romero, S., Casula, M. F., Gutiérrez, L., Morales, M. P., Böhm, I. B., Heverhagen, J. T., Prosperi, D., & Parak, W. J. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15337h · Cited by 1,315
Technical Challenges in Using Human Induced Pluripotent Stem Cells to Model Disease
Saha, K., & Jaenisch, R. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.11.009 · Cited by 411
New forms of superparamagnetic nanoparticles for biomedical applications
Xu, C., & Sun, S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.10.008 · Cited by 349
Engineered nanoparticles for biomolecular imaging
Mahmoudi, M., Serpooshan, V., & Laurent, S. (2011) · Nanoscale · doi:10.1039/c1nr10326a · Cited by 262
Horie, N., Pereira, M. P., Niizuma, K., Sun, G., Keren-Gill, H., Encarnacion, A., Shamloo, M., Hamilton, S. A., Jiang, K., Huhn, S., et al. (2011) · Stem Cells · doi:10.1002/stem.584 · Cited by 240
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Metadata
- Authors
- Guzman, R., Uchida, N., Bliss, T. M., He, D., Christopherson, K. K., Stellwagen, D., Capela, A., Greve, J., Malenka, R. C., Moseley, M. E., Palmer, T. D., & Steinberg, G. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-06-12
- Volume
- 104
- Issue
- 24
- Pages
- 10211-10216
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093667448
- Cited by
- 331
- References
- 1
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Guzman, R., Uchida, N., Bliss, T. M., He, D., Christopherson, K. K., Stellwagen, D., Capela, A., Greve, J., Malenka, R. C., Moseley, M. E., Palmer, T. D., & Steinberg, G. K. (2007). Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0608519104
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