New forms of superparamagnetic nanoparticles for biomedical applications
Abstract
Magnetic nanoparticles (MNPs) based on iron oxide, especially magnetite (Fe3O4), have been explored as sensitive probes for magnetic resonance imaging and therapeutic applications. Such application potentials plus the need to achieve high efficiency and sensitivity have motivated the search for new forms of superparamagnetic NPs with additional chemical and physical functionalities. This review summarizes the latest development of high moment MNPs, multifunctional MNPs, and porous hollow MNPs for biosensing, molecular imaging, and drug delivery applications.
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Many iron oxide nanoparticles have been evaluated in preclinical and clinical trials, and several have reached the market.
“Many iron oxide nanoparticles have been evaluated in preclinical and clinical trials, and several of them have reached the market (Table 1) [4, 22–26].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [24]
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- Authors
- Xu, C., & Sun, S.
- Affiliations
- Nanyang Technological University (SG)
- Brown University (US)
- Corresponding author
- Xu, Chenjie
- Sun, Shouheng
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 65
- Issue
- 5
- Pages
- 732-743
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2010177878
- Cited by
- 349
- References
- 128
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 17 · 2023: 23 · 2022: 14 · 2021: 27 · 2020: 35 · 2019: 22 · 2018: 41 · 2017: 34 · 2016: 37 · 2015: 38 · 2014: 30 · 2013: 11
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- DR-NTU (Nanyang Technological University) (submittedVersion)
- Funders
- Nanyang Technological University
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Keywords
- superparamagnetic nanoparticles, iron oxide nanoparticles, magnetite, multifunctional nanoparticles, MRI contrast agents, biosensing, molecular imaging, drug delivery, magnetic hyperthermia
- MeSH terms
- Animals, Humans, Drug Delivery Systems, Biomedical Technology, Molecular Imaging, Magnetite Nanoparticles
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