Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function

The CCP4 suite: programs for protein crystallography

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Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

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Likelihood-enhanced fast translation functions

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Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever

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Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

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SMART 5: domains in the context of genomes and networks

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TRIM family proteins: retroviral restriction and antiviral defence

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Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor

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Antibody Multispecificity Mediated by Conformational Diversity

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Hare TRIM5α Restricts Divergent Retroviruses and Exhibits Significant Sequence Variation from Closely Related Lagomorpha TRIM5 Genes

Fletcher, A. J., Hué, S., Schaller, T., Pillay, D., & Towers, G. J. (2010) · Journal of Virology · doi:10.1128/jvi.01514-10 · Cited by 26

Different subcellular localisations of TRIM22 suggest species-specific function

Herr, A.-M., Dressel, R., & Walter, L. (2009) · Immunogenetics · doi:10.1007/s00251-009-0357-z · Cited by 24

Down-regulation of tripartite motif protein 59 inhibits proliferation, migration and invasion in breast cancer cells

Zhang, Y., & Yang, W. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.039 · Cited by 24

A framework for TRIM21-mediated protein depletion in early mouse embryos: recapitulation of Tead4 null phenotype over three days

Israel, S., Casser, E., Drexler, H. C. A., Fuellen, G., & Boiani, M. (2019) · BMC Genomics · doi:10.1186/s12864-019-6106-2 · Cited by 26

The role of inflammatory cytokines and NF-κB/MAPK signaling pathways in the evolution of familial Mediterranean fever: Current clinical perspectives and potential therapeutic approaches

Haddad, J. J. (2009) · Cellular Immunology · doi:10.1016/j.cellimm.2009.08.003 · Cited by 24

Ro52/TRIM21-deficient expression and function in different subsets of peripheral blood mononuclear cells is associated with a proinflammatory cytokine response in patients with idiopathic inflammatory myopathies

Gómez‐Martín, D., Galindo‐Feria, A. S., Barrera‐Vargas, A., Merayo‐Chalico, J., Juárez‐Vega, G., Torres-Ruiz, J. J., & Alcocer-Varela, J. C. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12914 · Cited by 23

Intracellular Antibody Immunity

Watkinson, R. E., McEwan, W. A., & James, L. C. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0017-4 · Cited by 22

Life History of the Oldest Lentivirus: Characterization of ELVgv Integrations in the Dermopteran Genome

Hron, T., Farkašová, H., Padhi, A., Pačes, J., & Elleder, D. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw149 · Cited by 22

Autoantibodies against the Immunoglobulin-Binding Region of Ro52 Link its Autoantigenicity with Pathogen Neutralization

Burbelo, P. D., Teos, L. Y., Herche, J. L., Iadarola, M. J., & Alevizos, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-21522-7 · Cited by 22

Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates

de Gialluly, M. A. S., Allen, A. R., Hayes, E. H., Zhuang, P., Goldfarb, R. B., Farrar, A. N., Federov, Y., & Adams, D. (2025) · Nature Communications · doi:10.1038/s41467-025-61818-7 · Cited by 23

Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein

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Intracellular Antibody Immunity and the Cytosolic Fc Receptor TRIM21

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Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation

Zhang, X., Pavličev, M., Jones, H. N., & Muglia, L. J. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz238 · Cited by 19

TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma

Tong, Q., Yi, M., Kong, P., Xu, L. S., Huang, W., Niu, Y., Gan, X., Zhan, H., Tian, R., & Yan, D. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02692-x · Cited by 23

The interconnected roles of TRIM21/Ro52 in systemic lupus erythematosus, primary Sjögren’s syndrome, cancers, and cancer metabolism

Hsu, C.-H., & Yu, Y. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03143-x · Cited by 20

The Human Immunodeficiency Virus Capsid Is More Than Just a Genome Package

James, L. C., & Jacques, D. A. (2018) · Annual Review of Virology · doi:10.1146/annurev-virology-092917-043430 · Cited by 18

Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21

Ng, P. M. L., Kaliaperumal, N., Lee, C. Y., Chin, W. J., Tan, H. C., Au, B. V., Goh, A. X., Tan, Q. W., Yeo, D. S. G., Connolly, J. E., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800462 · Cited by 20

Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21

McEwan, W. A. (2016) · Antibodies · doi:10.3390/antib5040021 · Cited by 19

Study of Sylvilagusrabbit TRIM5α species-specific domain: how ancient endoviruses could have shaped the antiviral repertoire in Lagomorpha

de Matos, A. L., van der Loo, W., Areal, H., Lanning, D. K., & Esteves, P. J. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-294 · Cited by 19

Negative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation

Guha, A., Nag, S., & Ray, P. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-68646-3 · Cited by 17

Antibody Fc-chimerism and effector functions: When IgG takes advantage of IgA

Cottignies-Calamarte, A., Tudor, D., & Bomsel, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1037033 · Cited by 23

Programmed Death Ligand 1 Regulatory Crosstalk with Ubiquitination and Deubiquitination: Implications in Cancer Immunotherapy

Kim, S.-B., Hwang, S., Cha, J.-Y., & Lee, H.-J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052939 · Cited by 19

The role of tripartite motif family members in mediating susceptibility to HIV-1 infection

Rahm, N., & Telenti, A. (2012) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e32835048e1 · Cited by 20

Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development

Su, X., Wu, C., Ye, X., Zeng, M., Zhang, Z., Che, Y., Zhang, Y., Liu, L., Lin, Y., & Yang, R. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0370-y · Cited by 18

Evolution of TRIM5 and TRIM22 in Bats Reveals a Complex Duplication Process

Fernandes, A. P., Águeda-Pinto, A., Pinheiro, A., Rebelo, H., & Esteves, P. J. (2022) · Viruses · doi:10.3390/v14020345 · Cited by 18

Synthetic biology approaches for targeted protein degradation

Chen, R. P., Gaynor, A. S., & Chen, W. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.107446 · Cited by 18

Mechanisms of Rhinovirus Neutralisation by Antibodies

Touabi, L., Aflatouni, F., & McLean, G. R. (2021) · Viruses · doi:10.3390/v13030360 · Cited by 17

Molecular characterization, tissue distribution and expression analysis of TRIM25 in Gallus gallus domesticus

Feng, Z.-Q., Cheng, Y., Yang, H., Zhu, Q. C., Yu, D., & Liu, Y. (2015) · Gene · doi:10.1016/j.gene.2015.02.025 · Cited by 17

New PROTAC Designs for Targeted Protein Degradation in 2021–2025: Novel E3 Ligases and Pre-PROTACs

Peng, W., Pan, X., Wang, S., Huang, G., & Qian, Y. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03330 · Cited by 19

Homology-based Identification of Capsid Determinants That Protect HIV1 from Human TRIM5α Restriction

Maillard, P. V., Zoete, V., Michielin, O. A., & Trono, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187609 · Cited by 16

Molecular recognition of Fc‐specific ligands binding onto the consensus binding site of IgG: insights from molecular simulation

Tong, H., Lin, D., Zhang, Q., Wang, R., & Yao, S. (2014) · Journal of Molecular Recognition · doi:10.1002/jmr.2373 · Cited by 16

Divergence of the vertebrate sp1A/ryanodine receptor domain and SOCS box-containing (Spsb) gene family and its expression and regulation within the mouse brain.

Kleiber, M. L., & Singh, S. M. (2009) · Genomics · doi:10.1016/j.ygeno.2008.11.011 · Cited by 18

TRIM21-driven K63-linked ubiquitination of RBM38c, as a novel interactor of BECN1, contributes to DNA damage-induced autophagy

Xia, L., Xing, Y., Ye, X., Wu, Y., Yang, Y., Yin, Z., Wang, A., Chen, J., & Zhang, M. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01480-0 · Cited by 14

A nanobody-based molecular toolkit for ubiquitin–proteasome system explores the main role of survivin subcellular localization

Miao, H., Liu, C., Ouyang, H., Zhang, P., Liu, Y., Zhang, C., Deng, C., Fu, Y., Niu, J., Zheng, W., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.952237 · Cited by 15

trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans

Yuan, L., Yuan, L., Li, P., Jing, H., & Zheng, Q. (2022) · eLife · doi:10.7554/elife.76436 · Cited by 16

Impact of a single amino acid in the variable region 2 of the Old World monkey TRIM5α SPRY (B30.2) domain on anti-human immunodeficiency virus type 2 activity

Kono, K., Bożek, K., Domingues, F. S., Shioda, T., & Nakayama, E. E. (2009) · Virology · doi:10.1016/j.virol.2009.03.004 · Cited by 15

A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects

Wines, B. D., Trist, H. M., Farrugia, W., Ngo, C., Trowsdale, J., Areschoug, T., Lindahl, G., Fraser, J. D., & Ramsland, P. A. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_6 · Cited by 14

A Litopenaeus vannamei TRIM32 gene is involved in oxidative stress response and innate immunity

Wang, L., Lu, K.-C., Chen, G., Li, M., Zhang, C., & Chen, Y.-H. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.11.002 · Cited by 14

Altered Expression of TRIM Proteins - Inimical Outcome and Inimitable Oncogenic Function in Breast Cancer with Diverse Carcinogenic Hallmarks

Mukherjee, S., & Ray, S. K. (2022) · Current Molecular Medicine · doi:10.2174/1566524022666220111122450 · Cited by 14

A Interacting Model: How TRIM21 Orchestrates with Proteins in Intracellular Immunity

Huang, Y., Gao, X., He, Q., & Liu, W.-T. (2023) · Small Methods · doi:10.1002/smtd.202301142 · Cited by 13

Identification of a second binding site on the TRIM25 B30.2 domain

D’Cruz, A. A., Kershaw, N. J., Hayman, T. J., Linossi, E. M., Chiang, J. J., Wang, M. K., Dagley, L. F., Kolesnik, T. B., Zhang, J., Masters, S. L., et al. (2017) · Biochemical Journal · doi:10.1042/bcj20170427 · Cited by 12

Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1

Sosa, C. J. M., Issoglio, F. M., & Carrizo, M. E. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100772 · Cited by 12

Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies.

Arase, N., Tsuji, H., Takamatsu, H., Jin, H., Konaka, H., Hamaguchi, Y., Tonomura, K., Kotobuki, Y., Ueda-Hayakawa, I., Matsuoka, S., et al. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102774 · Cited by 9

Deciphering roles of TRIMs as promising targets in hepatocellular carcinoma: current advances and future directions

Zhang, J., Zhou, Y., Feng, J., Xu, X., Wu, J., & Guo, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115538 · Cited by 12

Francisella tularensis Confronts the Complement System

Brock, S. R., & Parmely, M. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00523 · Cited by 12

The TRIM14 PRYSPRY domain mediates protein interaction via its basic interface

Yu, Y. F., Liang, L., Jin, Y., & Yin, Y. (2019) · FEBS Letters · doi:10.1002/1873-3468.13386 · Cited by 12

Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors

Sahin, M., Remy, M. M., Fallet, B., Sommerstein, R., Florova, M., Langner, A., Klausz, K., Straub, T., Kreutzfeldt, M., Wagner, I., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110303 · Cited by 10

Comparative structural analyses of the NHL domains from the human E3 ligase TRIM–NHL family

Chaikuad, A., Zhubi, R., Tredup, C., & Knapp, S. (2022) · IUCrJ · doi:10.1107/s2052252522008582 · Cited by 13

Redirecting the specificity of tripartite motif containing-21 scaffolds using a novel discovery and design approach

VanDyke, D., Xu, L., Sargunas, P. R., Gilbreth, R. N., Baca, M., Gao, C., Hunt, J., & Spangler, J. B. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105381 · Cited by 10

TRIM25, TRIM28 and TRIM59 and Their Protein Partners in Cancer Signaling Crosstalk: Potential Novel Therapeutic Targets for Cancer

Chiang, D. C., & Yap, B. K. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46100638 · Cited by 10

Porcine TRIM35 positively regulate TRAF3-mediated IFN-β production and inhibit Japanese encephalitis virus replication

Li, C., Zhou, Y., Xuan, C., Zhang, Y., Hu, J., Ren, C., Ding, J., Jiang, D., & Lǐ, Y. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104290 · Cited by 10

Alternative exon usage in TRIM21 determines the antigenicity of Ro52/TRIM21 in systemic lupus erythematosus

Gómez-Bañuelos, E., Wahadat, M. J., Li, J., Paz, M., Antiochos, B., Celia, A. I., Andrade, V., Ferris, D. P., GOLDMAN, D. W., Darrah, E., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.163795 · Cited by 10

Molecular Characterization and Expression Pattern of Tripartite Motif Protein 39 in Gallus gallus with a Complete PRY/SPRY Domain

Pan, C., Zhao, H., Lin, S., & Sheng, J. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12063797 · Cited by 10

Optimization of protein–protein docking for predicting Fc–protein interactions

Agostino, M., Mancera, R. L., Ramsland, P. A., & Fernández‐Recio, J. (2016) · Journal of Molecular Recognition · doi:10.1002/jmr.2555 · Cited by 10

Tripartite motif‐containing proteins precisely and positively affect host antiviral immune response

Wei, Y., Chen, S., Wang, M., & Cheng, A. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12669 · Cited by 11

The Multifunction of TRIM26: From Immune Regulation to Oncology

Zou, J., Niu, K., Lü, T., Kan, J., Cheng, H., & Xu, L. (2024) · Protein and Peptide Letters · doi:10.2174/0109298665311516240621114519 · Cited by 9

State-selective small molecule degraders that preferentially remove aggregates and oligomers

Lupták, J., Clift, D., Mukadam, A. S., Benn, J., Rhinesmith, T., McLaughlin, S. H., Dodds, A. C., Lapetaje, J. E., Sczaniecka-Clift, M., France, D. J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65454-z · Cited by 9

A rare null allele potentially encoding a dominant-negative TRIM5α protein in Baka pygmies

Torimiro, J. N. E., Javanbakht, H., Diaz‐Griffero, F., Kim, J., Carr, J. K., Carrington, M. N., Sawitzke, J., Burke, D. S., WOLFE, N. D., Dean, M. C., et al. (2009) · Virology · doi:10.1016/j.virol.2009.05.038 · Cited by 9

Cytosolic Internalization of Anti-DNA Antibodies by Human Monocytes Induces Production of Pro-inflammatory Cytokines Independently of the Tripartite Motif-Containing 21 (TRIM21)-Mediated Pathway

Park, H., Kim, M. J., Seo, Y., Ham, Y., Cho, M.-Y., & Kwon, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02019 · Cited by 9

Rare missense variants in the human cytosolic antibody receptor preserve antiviral function

Zeng, J., Slodkowicz, G., & James, L. C. (2019) · eLife · doi:10.7554/elife.48339 · Cited by 8

TRIM21 and Fc-engineered antibodies: decoding its complex antibody binding mode with implications for viral neutralization

Reusch, J., Franken, L. E., Then, J., Ringler, P., Butzer, J., Juroschek, T., Klein, C., Schlothauer, T., & Larivière, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1401471 · Cited by 8

Enterovirus Antibodies: Friends and Foes

Mbani, C. J., Morvan, C., Nekoua, M. P., Debuysschere, C., Alidjinou, E. K., Moukassa, D., & Hober, D. (2024) · Reviews in Medical Virology · doi:10.1002/rmv.70004 · Cited by 8

Identification and expression analysis of a Spsb gene in planarian Dugesia japonica

Dong, Z., Cheng, F., Yuwen, Y., Chen, J., Li, X., He, D., Zhang, H., Chen, G., & Liu, D. (2015) · Gene · doi:10.1016/j.gene.2015.03.032 · Cited by 8

CH2 domain orientation of human immunoglobulin G in solution: Structural comparison of glycosylated and aglycosylated Fc regions using small-angle X-ray scattering

Yageta, S., Imamura, H., Shibuya, R., & Honda, S. (2018) · mAbs · doi:10.1080/19420862.2018.1546086 · Cited by 8

Haprin‐deficient spermatozoa are incapable of in vitro fertilization

Aoki, Y., Tsujimura, A., Kaseda, K., Okabe, M., Tokuhiro, K., Ohta, T., O’Bryan, M. K., Okuda, H., KITAMURA, K., Ogawa, Y., et al. (2020) · Molecular Reproduction and Development · doi:10.1002/mrd.23344 · Cited by 8

Crystal structure of the SPRY domain-containing protein 7 reveals unique structural features

Yang, J., Guan, X., Zhang, D., Zhao, P., Guo, S., & Kuang, Z. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.07.076 · Cited by 8

hGRAD: A versatile “one-fits-all” system to acutely deplete RNA binding proteins from condensates

Arnold, B., Riegger, R. J., Okuda, E. K., Slišković, I., Keller, M., Bakisoglu, C., McNicoll, F., Zarnack, K., & Müller-McNicoll, M. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202304030 · Cited by 7

An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer

Ding, Y., Lu, Y., Guo, J., Chen, S., Han, X., Wang, S., Zhang, M., Wang, R., Song, J., Wang, K., et al. (2024) · Human Genomics · doi:10.1186/s40246-024-00631-7 · Cited by 7

The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Sarri, N., Papadopoulos, N., Lennartsson, J., & Heldin, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097782 · Cited by 7

Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer

Weng, C., Jin, R., Jin, X., Yang, Z., He, C., Zhang, Q., Xu, J., & Lv, B. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s482340 · Cited by 7

Updating on Roles of HIV Intrinsic Factors: A Review of Their Antiviral Mechanisms and Emerging Functions

Hadpech, S., Moonmuang, S., Chupradit, K., Yasamut, U., & Tayapiwatana, C. (2021) · Intervirology · doi:10.1159/000519241 · Cited by 8

Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection

Pellman, J., Goldstein, A., & Slabicki, M. M. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230324 · Cited by 6

TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms

Zhang, L., Wang, Q., Li, X., Cheng, X., Cai, L., Guo, A., Zhang, L., Hu, H., Wu, M., Li, X., et al. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00473 · Cited by 7

Human FcRL5 is an Fc receptor that simultaneously engages two IgGs

Chen, S., Li, S., Zhang, Z., & Xiao, J. (2026) · Science Advances · doi:10.1126/sciadv.aeb8865 · Cited by 6

Therapeutic Potential of Curcumin in Diabetic Cardiomyopathy: Modulation of Pyroptosis Pathways

Wang, F., Liu, L., Wang, J., Zhou, Y., Feng, X., & Liu, K. (2025) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-024-07644-3 · Cited by 8

Autoantibodies reactive to PEP08 are clinically related with morbidity and severity of interstitial lung disease in connective tissue diseases

Okumura, M., Ozawa, T., Hamana, H., Norimatsu, Y., Tsuda, R., Kobayashi, E., Shinoda, K., Taki, H., Tobe, K., Imura, J., et al. (2018) · European Journal of Immunology · doi:10.1002/eji.201747381 · Cited by 6

A Novel TRIM9 Protein Promotes NF-κB Activation Through Interacting With LvIMD in Shrimp During WSSV Infection

Sun, M., Li, S., Jin, S., Li, X., Xiang, J., & Li, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.819881 · Cited by 6

Anti-L1 antibody-bound HPV16 pseudovirus is degraded intracellularly via TRIM21/proteasomal pathway

Li, M., Huang, J., Zhu, Y., Huang, Z., Zhang, G., & Huang, J. (2022) · Virology Journal · doi:10.1186/s12985-022-01826-x · Cited by 6

Not so unique to Primates: The independent adaptive evolution of TRIM5 in Lagomorpha lineage

Águeda-Pinto, A., de Matos, A. L., Pinheiro, A., Neves, F., de Sousa-Pereira, P., & Esteves, P. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226202 · Cited by 6

TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases

Panlu, K., Wang, Y., Zhu, X., Lin, Z., Fang, T., Yao, X., Xie, Z., & Wang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1695818 · Cited by 6

International expert consensus recommendations on standardised nomenclature of SSA/Ro (TROVE2/Ro60 and TRIM21/Ro52) autoantibodies in autoimmune diseases

Nikolic, R. P. A., Ben‐Chetrit, E., Fritzler, M. J., Buhler, K. A., Shokravi, A., Barreth, N., Chan, E. K. L., Andrade, L. E. C., Lin, M., Grewal, J., et al. (2026) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2026.04.007 · Cited by 5

Intracellular antibody immunity and its applications

Zeng, J., & James, L. C. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008657 · Cited by 5

An AKT1-and TRIM21-mediated phosphodegron controls proteasomal degradation of HuR enabling cell survival under heat shock

Nag, S., Rahaman, S., Guha, A., & Ray, P. S. (2023) · iScience · doi:10.1016/j.isci.2023.106307 · Cited by 5

Validation of an indirect ELISA assay for assessment of autoantibodies against full-length TRIM21 and its individual domains

Dahl, M. L. N., Mikkelsen, J. H., Hvid, M., Korsholm, T., Nielsen, K. O., Andersen, C. B. F., Greisen, S. R., & Deleuran, B. W. (2023) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2023.2221862 · Cited by 5

A SPRY domain-containing SOCS box protein 3 (SPSB3) involved in the regulation of cytokine production in granulocytes of Crassostrea gigas

Wang, M., Liu, C., Wang, W., Dong, M., Zhang, P., Liu, Y., Wang, L., & Song, L. (2019) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2019.01.013 · Cited by 5

Hepadnaviruses have a narrow host range — do they?

Dallmeier, K., & Nassal, M. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8558-3_14 · Cited by 5

NKAPL suppresses NSCLC progression by enhancing the protein stability of TRIM21 and further inhibiting the NF-κB signaling pathway

Li, C., Wang, Q., Dai, F., Xiang, X., Lin, Y., Shao, B., Li, Q., Peng, X., Li, R., Luo, F., et al. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101598 · Cited by 4

Mechanisms and Design Principles of Proteolysis-Targeting Chimeras and Their Emerging Applications

Knoll, N., Neamati, N., & Üren, A. (2026) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00730 · Cited by 5

Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain

Kim, Y., Lučić, A., Lenz, C., Farges, F., Schwalm, M. P., Saxena, K., Hanke, T., Marples, P. G., Aschenbrenner, J. C., Fearon, D., et al. (2025) · Communications Chemistry · doi:10.1038/s42004-025-01574-3 · Cited by 4

Evolution and expression of the duck TRIM gene repertoire

Campbell, L. K., Peery, R. M., & Magor, K. E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1220081 · Cited by 4

Application of A lpha F old models in evaluating ligandable cysteines across E 3 ligases

Koldenhof, P., Bemelmans, M. P., Ghosh, B. K., Damm‐Ganamet, K. L., van Vlijmen, H., & Pande, V. (2024) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26675 · Cited by 5

LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

Kim, Y., Knapp, S., & Krämer, A. (2025) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x25000913 · Cited by 4

A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases

Hage, A., Janes, M., & Best, S. M. (2025) · Viruses · doi:10.3390/v17040562 · Cited by 4

Antibodies against Adenoviruses

Byrnes, A. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800276-6.00015-2 · Cited by 4

Stellabody: A novel hexamer‐promoting mutation for improved IgG potency

Whitehead, C. A., Wines, B. D., Davies, A. M., McDonnell, J. M., Trist, H. M., Esparon, S. E., & Hogarth, P. M. (2024) · Immunological Reviews · doi:10.1111/imr.13400 · Cited by 4

Interaction of Mycobacterium tuberculosis ESAT-6 protein with ADAM9 protein

Huixing, L., & Aihui, C. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr10.856 · Cited by 4

Significance of Selective Protein Degradation in the Development of Novel Targeted Drugs and Its Implications in Cancer Therapy

Yang, J., Wang, Q.-L., Feng, G., & Zeng, M. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900210 · Cited by 4

Structural Basis of a Conventional Recognition Mode of IGHV1-69 Rheumatoid Factors

Shiroishi, M. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_510 · Cited by 3

The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death

Evans, E. L. J., Demarco, B., Cai, H., de Jong, M. M. E., Hill, S., Widdess, M. A., Fergusson, J. R., Glass, R. E., Harris, G., Mead, G., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.ads9680 · Cited by 4

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved

Keeble, A. H., Khan, Z., Forster, A., & James, L. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800159105 · Cited by 202

TRIM21 is a trimeric protein that binds IgG Fc via the B30.2 domain

Rhodes, D. A., & Trowsdale, J. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.10.013 · Cited by 95

TRIM protein domain topology and implications for antiviral immunity

Jacques, D. A., Jeffries, C. M., Caines, M. E. C., Lammers, M., Mallery, D. L., Price, A. J., McLaughlin, S. H., Johnson, C. M., Svergun, D. I., & James, L. C. (2014) · Acta Crystallographica Section A Foundations and Advances · doi:10.1107/s2053273314097563

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction

Yang, Y., Brandariz-Núñez, A., Fricke, T., Ivanov, D. N., Sarnak, Z., & Diaz‐Griffero, F. (2013) · Virology · doi:10.1016/j.virol.2013.10.012 · Cited by 32

Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module

Biris, N., Yang, Y., Taylor, A. B., Tomashevski, A., Guo, M., Hart, P. J., Diaz‐Griffero, F., & Ivanov, D. N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203536109 · Cited by 91