The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility
Open accessAbstract
Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel, mutations of which cause cystic fibrosis, a disease characterized by defective Cl − and HCO 3 − transport. Although >95% of all CF male patients are infertile because of congenital bilateral absence of the vas deferens (CBAVD), the question whether CFTR mutations are involved in other forms of male infertility is under intense debates. Here we report that CFTR is detected in both human and mouse sperm. CFTR inhibitor or antibody significantly reduces the sperm capacitation, and the associated HCO 3 − -dependent events, including increases in intracellular pH, cAMP production and membrane hyperpolarization. The fertilizing capacity of the sperm obtained from heterozygous CFTR mutant mice is also significantly lower compared with that of the wild-type. These results suggest that CFTR in sperm may be involved in the transport of HCO 3 − important for sperm capacitation and that CFTR mutations with impaired CFTR function may lead to reduced sperm fertilizing capacity and male infertility other than CBAVD.
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Cites
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
Welsh, M. J., & Smith, A. E. (1993) · Cell · doi:10.1016/0092-8674(93)90353-r · Cited by 1,485
Soluble Adenylyl Cyclase as an Evolutionarily Conserved Bicarbonate Sensor
Chen, Y., Cann, M. J., Litvin, T. N., Iourgenko, V., Sinclair, M. L., Levin, L. R., & Buck, J. (2000) · Science · doi:10.1126/science.289.5479.625 · Cited by 846
Cited by
Calcium Channels in the Development, Maturation, and Function of Spermatozoa
Darszon, A., Nishigaki, T., Beltran, C., & Treviño, C. L. (2011) · Physiological Reviews · doi:10.1152/physrev.00028.2010 · Cited by 364
Ion channels, phosphorylation and mammalian sperm capacitation
Visconti, P. E., Krapf, D., de la Vega-Beltrán, J. L., Acevedo, J. J., & Darszon, A. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2010.69 · Cited by 327
Molecular Basis of Human Sperm Capacitation
Puga Molina, L. C., Luque, G. M., Balestrini, P. A., Marín-Briggiler, C. I., Romarowski, A., & Buffone, M. G. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00072 · Cited by 256
Genetic abnormalities leading to qualitative defects of sperm morphology or function
Ray, P. F., Toure, A., Metzler‐Guillemain, C., Mitchell, M. J., Arnoult, C., & Coutton, C. (2017) · Clinical Genetics · doi:10.1111/cge.12905 · Cited by 179
Guo, J. H., Chen, H., Ruan, Y. C., Zhang, X. L., Zhang, X. H., Fok, K. L., Tsang, L. L., Yu, M. K., Huang, W. Q., Sun, X., et al. (2014) · Nature Communications · doi:10.1038/ncomms5420 · Cited by 157
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Metadata
- Authors
- Xu, W. M., Shi, Q. X., Chen, W. Y., Zhou, C. X., Ni, Y., Rowlands, D. K., Yi Liu, G., Zhu, H., Ma, Z. G., Wang, X. F., Chen, Z. H., Zhou, S. C., Dong, H. S., Zhang, X. H., Chung, Y. W., Yuan, Y. Y., Yang, W. X., & Chan, H. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-06-05
- Volume
- 104
- Issue
- 23
- Pages
- 9816-9821
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087303049
- Cited by
- 204
- References
- 2
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Xu, W. M., Shi, Q. X., Chen, W. Y., Zhou, C. X., Ni, Y., Rowlands, D. K., Yi Liu, G., Zhu, H., Ma, Z. G., Wang, X. F., Chen, Z. H., Zhou, S. C., Dong, H. S., Zhang, X. H., Chung, Y. W., Yuan, Y. Y., Yang, W. X., & Chan, H. C. (2007). Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0609253104
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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