The DOI matches its Crossref record; 407 of the 407 references it cites were found in a registry or an index.
Calcium Channels in the Development, Maturation, and Function of Spermatozoa
Abstract
A proper dialogue between spermatozoa and the egg is essential for conception of a new individual in sexually reproducing animals. Ca 2+is crucial in orchestrating this unique event leading to a new life. No wonder that nature has devised different Ca 2+-permeable channels and located them at distinct sites in spermatozoa so that they can help fertilize the egg. New tools to study sperm ionic currents, and image intracellular Ca 2+with better spatial and temporal resolution even in swimming spermatozoa, are revealing how sperm ion channels participate in fertilization. This review critically examines the involvement of Ca 2+channels in multiple signaling processes needed for spermatozoa to mature, travel towards the egg, and fertilize it. Remarkably, these tiny specialized cells can express exclusive channels like CatSper for Ca 2+and SLO3 for K+, which are attractive targets for contraception and for the discovery of novel signaling complexes. Learning more about fertilization is a matter of capital importance; societies face growing pressure to counteract rising male infertility rates, provide safe male gamete-based contraceptives, and preserve biodiversity through improved captive breeding and assisted conception initiatives.
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Cites
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Cited by
Ion channels, phosphorylation and mammalian sperm capacitation
Visconti, P. E., Krapf, D., de la Vega-Beltrán, J. L., Acevedo, J. J., & Darszon, A. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2010.69 · Cited by 327
Self-citationMolecular Basis of Human Sperm Capacitation
Puga Molina, L. C., Luque, G. M., Balestrini, P. A., Marín-Briggiler, C. I., Romarowski, A., & Buffone, M. G. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00072 · Cited by 256
Chemical UV filters mimic the effect of progesterone on Ca2+ signaling in human sperm cells
Rehfeld, A., Dissing, S., & Skakkebæk, N. E. (2016) · Endocrinology · doi:10.1210/en.2016-1473 · Cited by 56
Metadata
- Authors
- Darszon, A., Nishigaki, T., Beltran, C., & Treviño, C. L.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2011-10
- Volume
- 91
- Issue
- 4
- Pages
- 1305-1355
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2147437660
- Cited by
- 364
- References
- 407
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
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