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Cited by 334

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Magnetic microposts as an approach to apply forces to living cells

Open access
Sniadecki, Nathan J., Anguelouch, Alexandre, Yang, Michael T., Lamb, Corinne M., Liu, Zhijun, Kirschner, Stuart B., Liu, Yaohua, Reich, Daniel H., Chen, Christopher S.·2007·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0611613104
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Abstract

Cells respond to mechanical forces whether applied externally or generated internally via the cytoskeleton. To study the cellular response to forces separately, we applied external forces to cells via microfabricated magnetic posts containing cobalt nanowires interspersed among an array of elastomeric posts, which acted as independent sensors to cellular traction forces. A magnetic field induced torque in the nanowires, which deflected the magnetic posts and imparted force to individual adhesions of cells attached to the array. Using this system, we examined the cellular reaction to applied forces and found that applying a step force led to an increase in local focal adhesion size at the site of application but not at nearby nonmagnetic posts. Focal adhesion recruitment was enhanced further when cells were subjected to multiple force actuations within the same time interval. Recording the traction forces in response to such force stimulation revealed two responses: a sudden loss in contractility that occurred within the first minute of stimulation or a gradual decay in contractility over several minutes. For both types of responses, the subcellular distribution of loss in traction forces was not confined to locations near the actuated micropost, nor uniformly across the whole cell, but instead occurred at discrete locations along the cell periphery. Together, these data reveal an important dynamic biological relationship between external and internal forces and demonstrate the utility of this microfabricated system to explore this interaction.

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Metadata

Authors
Sniadecki, N. J., Anguelouch, A., Yang, M. T., Lamb, C. M., Liu, Z., Kirschner, S. B., Liu, Y., Reich, D. H., & Chen, C. S.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2007-09-11
Volume
104
Issue
37
Pages
14553-14558
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0611613104
OpenAlex
W2113220609
Cited by
334
References
30
FWCI
7.81
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Magnetic microposts as an approach to apply forces to living cells. https://app.cochat.ai/papers/10.1073/pnas.0611613104
The paper
Sniadecki, N. J., Anguelouch, A., Yang, M. T., Lamb, C. M., Liu, Z., Kirschner, S. B., Liu, Y., Reich, D. H., & Chen, C. S. (2007). Magnetic microposts as an approach to apply forces to living cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0611613104

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