The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
Abstract
▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control. The assembly of focal adhesions is regulated by the GTP-binding protein Rho. Rho stimulates contractility which, in cells that are tightly adherent to the substrate, generates isometric tension. In turn, this leads to the bundling of actin filaments and the aggregation of integrins (extracellular matrix receptors) in the plane of the membrane. The aggregation of integrins activates the focal adhesion kinase and leads to the assembly of a multicomponent signaling complex.
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Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
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Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
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Control of nonmuscle myosins by phosphorylation
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Stat1 Depends on Transcriptional Synergy with Sp1
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Cited by
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
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Taking Cell-Matrix Adhesions to the Third Dimension
Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027
The mechanisms of muscle hypertrophy and their application to resistance training
Schoenfeld, B. J. (2010) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181e840f3 · Cited by 1,214
Metadata
- Authors
- Burridge, K., & Chrzanowska-Wodnicka, M.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1996-11
- Volume
- 12
- Issue
- 1
- Pages
- 463-519
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2167956058
- Cited by
- 1,942
- References
- 7
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burridge, K., & Chrzanowska-Wodnicka, M. (1996). FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.12.1.463
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
