Cited by 136Amino Acid Enzymes and MetabolismNeuroscience and Neuropharmacology ResearchNitric Oxide and Endothelin Effects

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Nitric oxide S -nitrosylates serine racemase, mediating feedback inhibition of d -serine formation

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Mustafa, Asif K., Kumar, Manish, Selvakumar, Balakrishnan, Ho, Gary P. H., Ehmsen, Jeffrey T., Barrow, Roxanne K., Amzel, L. Mario, Snyder, Solomon H.·2007·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0611620104PMC PMC1815287

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Abstract

Serine racemase (SR) generates D-serine, a coagonist with glutamate at NMDA receptors. We show that SR is physiologically S-nitrosylated leading to marked inhibition of enzyme activity. Inhibition involves interactions with the cofactor ATP reflecting juxtaposition of the ATP-binding site and cysteine-113 (C113), the site for physiological S-nitrosylation. NMDA receptor physiologically enhances SR S-nitrosylation by activating neuronal nitric-oxide synthase (nNOS). These findings support a model whereby postsynaptic stimulation of nitric-oxide (NO) formation feeds back to presynaptic cells to S-nitrosylate SR and decrease D-serine availability to postsynaptic NMDA receptors.

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Authors: Mustafa, A. K., Kumar, M., Selvakumar, B., Ho, G. P. H., Ehmsen, J. T., Barrow, R. K., Amzel, L. M., & Snyder, S. H.
Affiliations: *Solomon H. Snyder Department of Neuroscience and
Departments of †Biophysics and Biophysical Chemistry,
Johns Hopkins University (US)
ORCID: Kumar, Manish
Selvakumar, Balakrishnan
Ho, Gary P. H.
Ehmsen, Jeffrey T.
Amzel, L. Mario
Snyder, Solomon H.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2007-02-20
Volume: 104
Issue: 8
Pages: 2950-2955
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0611620104
PMC: PMC1815287
OpenAlex: W2147808921
Cited by: 136
References: 21
Citations by year: 2026: 2 · 2025: 1 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 13
FWCI: 5.63
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
National Institute on Drug Abuse (DA 00074, K05DA000074)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: serine racemase, S-nitrosylation, D-serine, NMDA receptor co-agonist, product inhibition, ATP binding site, neuronal nitric oxide synthase, nitric oxide, presynaptic modulation
MeSH terms: Serine Racemase, Adenosine Triphosphate, Amino Acid Sequence, Animals, Coenzymes, Cysteine, Enzyme Activation, Humans, Models, Molecular, Models, Neurological, Molecular Sequence Data, Nitric Oxide, Serine, Receptors, N-Methyl-D-Aspartate, Racemases and Epimerases, Feedback, Physiological, S-Nitrosoglutathione, Mice, Nitric Oxide Synthase Type I

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Nitric oxide S -nitrosylates serine racemase, mediating feedback inhibition of d -serine formation

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