The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
An approach to electrical modeling of single and multiple cells
Open accessAbstract
Previous theoretical approaches to understanding effects of electric fields on cells have used partial differential equations such as Laplace's equation and cell models with simple shapes. Here we describe a transport lattice method illustrated by a didactic multicellular system model with irregular shapes. Each elementary membrane region includes local models for passive membrane resistance and capacitance, nonlinear active sources of the resting potential, and a hysteretic model of electroporation. Field amplification through current or voltage concentration changes with frequency, exhibiting significant spatial heterogeneity until the microwave range is reached, where cellular structure becomes almost "electrically invisible." In the time domain, membrane electroporation exhibits significant heterogeneity but occurs mostly at invaginations and cell layers with tight junctions. Such results involve emergent behavior and emphasize the importance of using multicellular models for understanding tissue-level electric field effects in higher organisms.
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“as the frequency of the field increases, the high membrane field gain diminishes, allowing for higher field intensities to penetrate into the cell.”
From An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields (2016) · cites this paper as [32]
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1 retracted
Non-thermal heat-shock response to microwaves
de Pomerai, D. I., Daniells, C., David, H. E., Allan, J., DUCE, I. R., Mutwakil, M. H. A. Z., Thomas, D. W. P., Sewell, P., Tattersall, J. E. H., Jones, D., et al. (2000) · Nature · doi:10.1038/35013144 · Cited by 233
RetractedStrogatz, S. H. (2001) · Nature · doi:10.1038/35065725 · Cited by 8,236
Ionic channels of excitable membranes
(1985) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(85)90172-7 · Cited by 7,134
Ionic channels of excitable membranes
(1985) · International Journal of Biochemistry · doi:10.1016/0020-711x(85)90073-4 · Cited by 1,083
High-efficiency gene transfer into skeletal muscle mediated by electric pulses.
Mir, L. M., Bureau, M., Gehl, J., Rangara, R., Rouy, D., Caillaud, J., Delaère, P., Branellec, D., Schwartz, B., & Scherman, D. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.8.4262 · Cited by 972
Electroporation and Electrofusion in Cell Biology
Neumann, E., Sowers, A. E., & Jordan, C. A. (1989) · Springer eBooks · doi:10.1007/978-1-4899-2528-2 · Cited by 947
CRC Handbook of Biological Effects of Electromagnetic Fields
Polk, C. (2019) · CRC Press eBooks · doi:10.1201/9781351071017 · Cited by 936
Guide to Electroporation and Electrofusion
Chang, D. C., Saunders, J. A., Chassy, B. M., & Sowers, A. E. (1992) · Elsevier eBooks · doi:10.1016/c2009-0-21564-9 · Cited by 640
Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery.
Prausnitz, M. R., Bose, V. G., Langer, R., & Weaver, J. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10504 · Cited by 640
Magnetite biomineralization in the human brain.
Kirschvink, J. L., Kobayashi-Kirschvink, A., & Woodford, B. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7683 · Cited by 615
Research works printed but not linked: 1
- D C Mikulecky Applications of Network Thermodynamics to Problems in Biomedical Engineering (New York Univ. Press, New York, 1993).
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Items 201–204 of 204
Sieni, E., Lamberti, P., Polichetti, M., Modestino, M. R., Galluzzi, A., Kralj, S., Kolosnjaj‐Tabi, J., Forzan, M., & Tucci, V. (2026) · Applied Sciences · doi:10.3390/app16147089
Pulsed electric fields in oncology: Mechanisms, technologies, and clinical frontiers
Liu, H., Dong, S., Zhao, Y., Yu, L., & Yao, C. (2026) · Pulsed Power · doi:10.1016/j.pup.2026.100026
Lebovka, N., & Vorobiev, E. (2026) · Springer eBooks · doi:10.1007/978-3-319-26779-1_9-2
Metadata
- Authors
- Gowrishankar, T. R., & Weaver, J. C.
- Affiliations
- Harvard–MIT Division of Health Sciences and Technology (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2003-03-07
- Volume
- 100
- Issue
- 6
- Pages
- 3203-3208
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC152270
- OpenAlex
- W2146657034
- Cited by
- 204
- References
- 46
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 15 · 2017: 10 · 2016: 15 · 2015: 10 · 2014: 9 · 2013: 6 · 2012: 10
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- electric field effects on cells, multicellular models, resting membrane potential, electroporation, hysteresis, field enhancement, tight junctions, cell invagination, emergent behavior
- MeSH terms
- Cells, Electric Conductivity, Electrolytes, Electromagnetic Fields, Ion Channels, Membrane Potentials, Models, Biological, Electroporation
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