Cited by 204Electromagnetic Fields and Biological EffectsMicrobial Inactivation MethodsNeural dynamics and brain function

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An approach to electrical modeling of single and multiple cells

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Gowrishankar, Thiruvallur R., Weaver, James C.·2003·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0636434100PMC PMC152270

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Abstract

Previous theoretical approaches to understanding effects of electric fields on cells have used partial differential equations such as Laplace's equation and cell models with simple shapes. Here we describe a transport lattice method illustrated by a didactic multicellular system model with irregular shapes. Each elementary membrane region includes local models for passive membrane resistance and capacitance, nonlinear active sources of the resting potential, and a hysteretic model of electroporation. Field amplification through current or voltage concentration changes with frequency, exhibiting significant spatial heterogeneity until the microwave range is reached, where cellular structure becomes almost "electrically invisible." In the time domain, membrane electroporation exhibits significant heterogeneity but occurs mostly at invaginations and cell layers with tight junctions. Such results involve emergent behavior and emphasize the importance of using multicellular models for understanding tissue-level electric field effects in higher organisms.

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Authors: Gowrishankar, T. R., & Weaver, J. C.
Affiliations: Harvard–MIT Division of Health Sciences and Technology (US)
ORCID: Gowrishankar, Thiruvallur R.
Weaver, James C.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2003-03-07
Volume: 100
Issue: 6
Pages: 3203-3208
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0636434100
PMC: PMC152270
OpenAlex: W2146657034
Cited by: 204
References: 46
Citations by year: 2026: 4 · 2025: 1 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 7 · 2018: 15 · 2017: 10 · 2016: 15 · 2015: 10 · 2014: 9 · 2013: 6 · 2012: 10
FWCI: 7.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Electromagnetic Fields and Biological Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: electric field effects on cells, multicellular models, resting membrane potential, electroporation, hysteresis, field enhancement, tight junctions, cell invagination, emergent behavior
MeSH terms: Cells, Electric Conductivity, Electrolytes, Electromagnetic Fields, Ion Channels, Membrane Potentials, Models, Biological, Electroporation

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An approach to electrical modeling of single and multiple cells

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