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Dealing with iron: Common structural principles in proteins that transport iron and heme
Open accessAbstract
Iron is essential to life, but poses severe problems because of its toxicity and the insolubility of hydrated ferric ions at neutral pH. In animals, a family of proteins called transferrins are responsible for the sequestration, transport, and distribution of free iron. Comparison of the structure and function of transferrins with a completely unrelated protein hemopexin, which carries out the same function for heme, identifies molecular features that contribute to a successful protein system for iron acquisition, transport, and release. These include a two-domain protein structure with flexible hinges that allow these domains to enclose the bound ligand and provide suitable chemistry for stable binding and an appropriate trigger for release.
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Citations
Cited by
Mechanisms of Cell Protection by Heme Oxygenase-1
Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105600 · Cited by 1,241
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
Structure of the human transferrin receptor-transferrin complex
Cheng, Y., Zak, O., Aisen, P., Harrison, S. C., & Walz, T. (2004) · Cell · doi:10.1016/s0092-8674(04)00130-8 · Cited by 571
Lactoferrin a multiple bioactive protein: an overview
García-Montoya, I. A., Cendón, T. S., Arévalo-Gallegos, S., & Rascón-Cruz, Q. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.06.018 · Cited by 473
Lactoferrin: Multifunctional roles of lactoferrin: a critical overview
Ward, P. P., Paz, E., & Conneely, O. M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5369-8 · Cited by 443
Metadata
- Authors
- Baker, H. M., Anderson, B. F., & Baker, E. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-03-17
- Volume
- 100
- Issue
- 7
- Pages
- 3579-3583
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066548059
- Cited by
- 243
- References
- 0
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Baker, H. M., Anderson, B. F., & Baker, E. N. (2003). Dealing with iron: Common structural principles in proteins that transport iron and heme. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0637295100
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