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The molecular basis of CO 2 reception in Drosophila
Open accessAbstract
CO 2 elicits a response from many insects, including mosquito vectors of diseases such as malaria and yellow fever, but the molecular basis of CO 2 detection is unknown in insects or other higher eukaryotes. Here we show that Gr21a and Gr63a , members of a large family of Drosophila seven-transmembrane-domain chemoreceptor genes, are coexpressed in chemosensory neurons of both the larva and the adult. The two genes confer CO 2 response when coexpressed in an in vivo expression system, the “empty neuron system.” The response is highly specific for CO 2 and dependent on CO 2 concentration. The response shows an equivalent dependence on the dose of Gr21a and Gr63a . None of 39 other chemosensory receptors confers a comparable response to CO 2 . The identification of these receptors may now allow the identification of agents that block or activate them. Such agents could affect the responses of insect pests to the humans they seek.
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Cites
A Novel Family of Divergent Seven-Transmembrane Proteins
Clyne, P. J., Warr, C. G., Freeman, M. R., Lessing, D., Kim, J., & Carlson, J. R. (1999) · Neuron · doi:10.1016/s0896-6273(00)81093-4 · Cited by 1,155
Self-citationWingrove, J. A., & O'Farrell, P. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80610-8 · Cited by 249
Cited by
Molecular Architecture of Smell and Taste in Drosophila
Vosshall, L. B., & Stocker, R. F. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094306 · Cited by 870
Liman, E. R., Zhang, Y. V., & Montell, C. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.022 · Cited by 473
The Molecular and Cellular Basis of Bitter Taste in Drosophila
Weiss, L. A., Dahanukar, A., Kwon, J. Y., Banerjee, D., & Carlson, J. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.001 · Cited by 440
Self-citationOdor Coding in the Maxillary Palp of the Malaria Vector Mosquito Anopheles gambiae
Lu, T., Qiu, Y. T., Wang, G., Kwon, J. Y., Rutzler, M., Kwon, H.-W., Pitts, R. J., van Loon, J. J. A., Takken, W., Carlson, J. R., et al. (2007) · Current Biology · doi:10.1016/j.cub.2007.07.062 · Cited by 371
Self-citationDrosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain
Joseph, R. M., & Carlson, J. R. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.09.005 · Cited by 370
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Metadata
- Authors
- Kwon, J. Y., Dahanukar, A., Weiss, L. A., & Carlson, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-02-27
- Volume
- 104
- Issue
- 9
- Pages
- 3574-3578
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007377332
- Cited by
- 500
- References
- 2
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- green
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