The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
Open accessAbstract
The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact biological processes. We have identified components of a Skp1-Cul1-F-Box E3 ligase complex that are required for the extended lifespan of Caenorhabditis elegans insulin/insulin-like growth factor-1-signaling (IIS) mutants. The CUL-1 complex functions in postmitotic, adult somatic tissues of IIS mutants to enhance longevity. Reducing IIS function leads to the nuclear accumulation of the DAF-16/FOXO transcription factor, which extends lifespan by regulating downstream longevity genes. These CUL-1 complex genes act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO. Together, our findings describe a role for an important cellular pathway, the proteasomal pathway, in the genetic determination of lifespan.
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“mutations in the genes of the CUL-1 E3 ligase complex shorten the extended lifespan of different insulin signaling C. elegans mutants (Ghazi et al., 2007)”
From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Ghazi et al., 2007
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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
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A C. elegans mutant that lives twice as long as wild type
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Self-citationGenes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
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Self-citationLin, K., Dorman, J. B., Rodan, A. R., & Kenyon, C. J. (1997) · Science · doi:10.1126/science.278.5341.1319 · Cited by 1,501
Self-citationThe plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Self-citationRates of Behavior and Aging Specified by Mitochondrial Function During Development
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Self-citationSignals from the reproductive system regulate the lifespan of C. elegans
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Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., García-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,789
FOXO3A genotype is strongly associated with human longevity
Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983
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Protein Homeostasis and Aging: the importance of exquisite quality control
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Metadata
- Authors
- Ghazi, A., Henis-Korenblit, S., & Kenyon, C.
- Affiliations
- University of California, San Francisco (US)
- Department of Biochemistry and Biophysics, University of California, Mission Bay Genentech Hall, 600 16th Street, San Francisco, CA 94158
- Corresponding author
- Kenyon, Cynthia
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2007-04-03
- Volume
- 104
- Issue
- 14
- Pages
- 5947-5952
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1851597
- OpenAlex
- W2047102030
- Cited by
- 134
- References
- 40
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 10 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 10 · 2013: 7 · 2012: 10
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Larry L. Hillblom Foundation
- National Institutes of Health
- National Institute on Aging (R01AG011816)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › FOXO transcription factor regulation
- Keywords
- Caenorhabditis elegans, lifespan extension, proteasome, E3 ubiquitin ligase, insulin/IGF-1 signaling, DAF-16/FOXO, aging, protein degradation, longevity genes, transcriptional regulation
- MeSH terms
- Animals, Gene Expression Regulation, Longevity, Caenorhabditis elegans, Animals, Genetically Modified, Ubiquitin-Protein Ligases, Proteasome Endopeptidase Complex
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