A C. elegans mutant that lives twice as long as wild type
Abstract
We have found that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type. This lifespan extension, the largest yet reported in any organism, requires the activity of a second gene, daf-16. Both genes also regulate formation of the dauer larva, a developmentally arrested larval form that is induced by crowding and starvation and is very long-lived. Our findings raise the possibility that the longevity of the dauer is not simply a consequence of its arrested growth, but instead results from a regulated lifespan extension mechanism that can be uncoupled from other aspects of dauer formation. daf-2 and daf-16 provide entry points into understanding how lifespan can be extended.
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Genes that regulate lifespan in animal models and human studies, and multiple experimental paradigms, have demonstrated that it is possible to manipulate ageing biology to rejuvenate physiological functioning in complex model organisms.
“Genes that regulate lifespan in animal models6–9 and human studies10–14 as well as multiple experimental paradigms, such as caloric restriction, heterochronic parabiosis and partial epigenetic reprogramming, have demonstrated that it is possible to manipulate ageing biology to ‘rejuvenate’ physiological functioning in complex model organisms15–28.”
From Measuring biological age using omics data (2022) · cites this paper as [9]
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Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae
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The metabolic regulation of aging
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Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae
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Mechanisms that Regulate Stem Cell Aging and Life Span
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Metabolism in T cell activation and differentiation
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- Authors
- Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Nature
- Published
- 1993-12
- Volume
- 366
- Issue
- 6454
- Pages
- 461-464
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2046989794
- Cited by
- 3,387
- References
- 22
- Citations by year
- 2026: 111 · 2025: 126 · 2024: 126 · 2023: 139 · 2022: 143 · 2021: 152 · 2020: 145 · 2019: 136 · 2018: 134 · 2017: 137 · 2016: 162 · 2015: 155 · 2014: 122 · 2013: 161 · 2012: 140
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Nematode management and characterization studies
- Keywords
- Caenorhabditis elegans, daf-2, DAF-16, lifespan extension, longevity, dauer larvae, hermaphrodite, insulin/IGF-1 signaling, genetic mutations
- MeSH terms
- Animals, Larva, Longevity, Mutation, Reproduction, Disorders of Sex Development, Temperature, Caenorhabditis elegans, Genes, Helminth
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