Cited by 3,387Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology ResearchNematode management and characterization studies

A C. elegans mutant that lives twice as long as wild type

Kenyon, Cynthia, Chang, Jean, Gensch, Erin, Rudner, Adam, Tabtiang, Ramon·1993·Nature

Abstract

We have found that mutations in the gene daf-2 can cause fertile, active, adult Caenorhabditis elegans hermaphrodites to live more than twice as long as wild type. This lifespan extension, the largest yet reported in any organism, requires the activity of a second gene, daf-16. Both genes also regulate formation of the dauer larva, a developmentally arrested larval form that is induced by crowding and starvation and is very long-lived. Our findings raise the possibility that the longevity of the dauer is not simply a consequence of its arrested growth, but instead results from a regulated lifespan extension mechanism that can be uncoupled from other aspects of dauer formation. daf-2 and daf-16 provide entry points into understanding how lifespan can be extended.

Integrity signals

Registry

Crossref · 10.1038/366461a0

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Genes that regulate lifespan in animal models and human studies, and multiple experimental paradigms, have demonstrated that it is possible to manipulate ageing biology to rejuvenate physiological functioning in complex model organisms.

    “Genes that regulate lifespan in animal models6–9 and human studies10–14 as well as multiple experimental paradigms, such as caloric restriction, heterochronic parabiosis and partial epigenetic reprogramming, have demonstrated that it is possible to manipulate ageing biology to ‘rejuvenate’ physiological functioning in complex model organisms15–28.”

    From Measuring biological age using omics data (2022) · cites this paper as [9]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R.
Affiliations
University of California, San Francisco (US)
Venue
Nature
Published
1993-12
Volume
366
Issue
6454
Pages
461-464
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2046989794
Cited by
3,387
References
22
Citations by year
2026: 111 · 2025: 126 · 2024: 126 · 2023: 139 · 2022: 143 · 2021: 152 · 2020: 145 · 2019: 136 · 2018: 134 · 2017: 137 · 2016: 162 · 2015: 155 · 2014: 122 · 2013: 161 · 2012: 140
FWCI
8.73
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Nematode management and characterization studies
Keywords
Caenorhabditis elegans, daf-2, DAF-16, lifespan extension, longevity, dauer larvae, hermaphrodite, insulin/IGF-1 signaling, genetic mutations
MeSH terms
Animals, Larva, Longevity, Mutation, Reproduction, Disorders of Sex Development, Temperature, Caenorhabditis elegans, Genes, Helminth

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review