The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins
Open accessAbstract
Hepatitis C virus (HCV) and triglyceride-rich very low-density lipoproteins (VLDLs) both are secreted uniquely by hepatocytes and circulate in blood in a complex. Here, we isolated from human hepatoma cells the membrane vesicles in which HCV replicates. These vesicles, which contain the HCV replication complex, are highly enriched in proteins required for VLDL assembly, including apolipoprotein B (apoB), apoE, and microsomal triglyceride transfer protein. In hepatoma cells that constitutively produce infectious HCV, HCV production is reduced by two agents that block VLDL assembly: an inhibitor of microsomal triglyceride transfer protein and siRNA directed against apoB. These results provide a possible explanation for the restriction of HCV production to the liver and suggest new cellular targets for treatment of HCV infection.
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Cites
RNAi-mediated gene silencing in non-human primates
Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature · doi:10.1038/nature04688 · Cited by 1,357
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
Cuchel, M., Bloedon, L. T., Szapary, P. O., Kolansky, D. M., Wolfe, M. L., Sarkis, A., Millar, J. S., Ikewaki, K., Siegelman, E. S., Gregg, R. E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061189 · Cited by 580
Very-low-density lipoprotein assembly and secretion
Shelness, G. S., & Sellers, J. A. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00008 · Cited by 309
Cited by
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,854
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
Scheel, T. K. H., & Rice, C. M. (2013) · Nature Medicine · doi:10.1038/nm.3248 · Cited by 554
Appel, N., Zayas, M., Miller, S., Krijnse-Locker, J., Schaller, T., Friebe, P., Kallis, S., Engel, U., & Bartenschlager, R. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000035 · Cited by 466
Nahmias, Y., Goldwasser, J., Casali, M., van Poll, D., Wakita, T., Chung, R. T., & Yarmush, M. L. (2008) · Hepatology · doi:10.1002/hep.22197 · Cited by 279
Abnormalities of lipid metabolism in hepatitis C virus infection
Negro, F. (2010) · Gut · doi:10.1136/gut.2009.192732 · Cited by 162
Metadata
- Authors
- Huang, H., Sun, F., Owen, D. M., Li, W., Chen, Y., Gale, M., & Ye, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-04-03
- Volume
- 104
- Issue
- 14
- Pages
- 5848-5853
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094733152
- Cited by
- 533
- References
- 3
- FWCI
- 28.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, H., Sun, F., Owen, D. M., Li, W., Chen, Y., Gale, M., & Ye, J. (2007). Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0700760104
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