The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Apolipoprotein B–dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin
Open accessAbstract
Hepatitis C virus (HCV) infects over 3% of the world population and is the leading cause of chronic liver disease worldwide. HCV has long been known to associate with circulating lipoproteins, and its interactions with the cholesterol and lipid pathways have been recently described. In this work, we demonstrate that HCV is actively secreted by infected cells through a Golgi-dependent mechanism while bound to very low density lipoprotein (vLDL). Silencing apolipoprotein B (ApoB) messenger RNA in infected cells causes a 70% reduction in the secretion of both ApoB-100 and HCV. More importantly, we demonstrate that the grapefruit flavonoid naringenin, previously shown to inhibit vLDL secretion both in vivo and in vitro , inhibits the microsomal triglyceride transfer protein activity as well as the transcription of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase and acyl-coenzyme A:cholesterol acyltransferase 2 in infected cells. Stimulation with naringenin reduces HCV secretion in infected cells by 80%. Moreover, we find that naringenin is effective at concentrations that are an order of magnitude below the toxic threshold in primary human hepatocytes and in mice. Conclusion: These results suggest a novel therapeutic approach for the treatment of HCV infection.
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Cites
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Self-citationRobust hepatitis C virus infection in vitro
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IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS
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Cited by
(−)-Epigallocatechin- 3 -gallate is a new inhibitor of hepatitis C virus entry
Calland, N., Albecka, A., Belouzard, S., Wychowski, C., Duverlie, G., Descamps, V., Hober, D., Dubuisson, J., Rouillé, Y., & Séron, K. (2012) · Hepatology · doi:10.1002/hep.24803 · Cited by 279
Abnormalities of lipid metabolism in hepatitis C virus infection
Negro, F. (2010) · Gut · doi:10.1136/gut.2009.192732 · Cited by 162
Meyer, M. S., Applebaum, K. M., Furniss, C. S., Peters, E. S., Luckett, B. G., Smith, J. F., Bryan, J., McClean, M. D., Marsit, C., & Kelsey, K. T. (2008) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0560 · Cited by 27
Metadata
- Authors
- Nahmias, Y., Goldwasser, J., Casali, M., van Poll, D., Wakita, T., Chung, R. T., & Yarmush, M. L.
- Venue
- Hepatology
- Published
- 2008-05
- Volume
- 47
- Issue
- 5
- Pages
- 1437-1445
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1970828145
- Cited by
- 279
- References
- 33
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nahmias, Y., Goldwasser, J., Casali, M., van Poll, D., Wakita, T., Chung, R. T., & Yarmush, M. L. (2008). Apolipoprotein B–dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. Hepatology. https://doi.org/10.1002/hep.22197
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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