The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus
Open accessAbstract
Lipoteichoic acid (LTA), a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. However, the molecular basis for its synthesis or function is not known. Here we report that Staphylococcus aureus LtaS synthesizes glycerol phosphate LTA. Construction of a mutant S. aureus strain with inducible ltaS expression revealed that LTA synthesis is required for bacterial growth and cell division. An ltaS homologue of Bacillus subtilis restored LTA synthesis and the growth of ltaS mutant staphylococci. Thus, LtaS inhibition can be used as a target to treat human infections caused by antibiotic-resistant S. aureus or other bacterial pathogens.
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Cites
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Howden, B. P., Davies, J. K., Johnson, P. D. R., Stinear, T. P., & Grayson, M. L. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-09 · Cited by 962
Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury
Lai, Y., Di Nardo, A., Nakatsuji, T., Leichtle, A., Yang, Y., Cogen, A. L., Wu, Z.-R., Hooper, L. V., Schmidt, R. R., von Aulock, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2062 · Cited by 781
The Gram-Positive Bacterial Cell Wall
Rohde, M. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0044-2018 · Cited by 319
The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection
Hara, H., Seregin, S. S., Yang, D., Fukase, K., Chamaillard, M., Alnemri, E. S., Inohara, N., Chen, G. Y., & Núñez, G. (2018) · Cell · doi:10.1016/j.cell.2018.09.047 · Cited by 308
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Metadata
- Authors
- Gründling, A., & Schneewind, O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-05-15
- Volume
- 104
- Issue
- 20
- Pages
- 8478-8483
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005518049
- Cited by
- 301
- References
- 46
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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