The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Histone modifications induced by a family of bacterial toxins
Open accessAbstract
Upon infection, pathogens reprogram host gene expression. In eukaryotic cells, genetic reprogramming is induced by the concerted activation/repression of transcription factors and various histone modifications that control DNA accessibility in chromatin. We report here that the bacterial pathogen Listeria monocytogenes induces a dramatic dephosphorylation of histone H3 as well as a deacetylation of histone H4 during early phases of infection. This effect is mediated by the major listerial toxin listeriolysin O in a pore-forming-independent manner. Strikingly, a similar effect also is observed with other toxins of the same family, such as Clostridium perfringens perfringolysin and Streptococcus pneumoniae pneumolysin. The decreased levels of histone modifications correlate with a reduced transcriptional activity of a subset of host genes, including key immunity genes. Thus, control of epigenetic regulation emerges here as an unsuspected function shared by several bacterial toxins, highlighting a common strategy used by intracellular and extracellular pathogens to modulate the host response early during infection.
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Cites
The human SWI/SNF subunit Brm is a regulator of alternative splicing
Batsché, E., Yaniv, M., & Muchardt, C. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1030 · Cited by 471
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Cited by
Transcriptional control of the inflammatory response
Medzhitov, R., & Horng, T. (2009) · Nature Reviews Immunology · doi:10.1038/nri2634 · Cited by 1,035
Pore-forming toxins: ancient, but never really out of fashion
Peraro, M. D., & van der Goot, F. G. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.3 · Cited by 788
Origins and virulence mechanisms of uropathogenic Escherichia coli
Wiles, T. J., Kulesus, R. R., & Mulvey, M. A. (2008) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2008.03.007 · Cited by 606
Listeriolysin O: the Swiss army knife of Listeria
Hamon, M. A., Ribet, D., Stavru, F., & Cossart, P. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.04.006 · Cited by 295
Self-citationA Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection
Eskandarian, H. A., Impens, F., Nahori, M.-A., Soubigou, G., Coppée, J.-Y., Cossart, P., & Hamon, M. A. (2013) · Science · doi:10.1126/science.1238858 · Cited by 267
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Metadata
- Authors
- Hamon, M. A., Batsché, E., Régnault, B., Tham, T. N., Seveau, S., Muchardt, C., & Cossart, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-08-14
- Volume
- 104
- Issue
- 33
- Pages
- 13467-13472
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2027151256
- Cited by
- 284
- References
- 1
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Hamon, M. A., Batsché, E., Régnault, B., Tham, T. N., Seveau, S., Muchardt, C., & Cossart, P. (2007). Histone modifications induced by a family of bacterial toxins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0702729104
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