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Cited by 606Escherichia coli research studiesUrinary Tract Infections ManagementBacterial Genetics and Biotechnology

Origins and virulence mechanisms of uropathogenic Escherichia coli

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Wiles, Travis J., Kulesus, Richard R., Mulvey, Matthew A.·2008·Experimental and Molecular Pathology
DOI 10.1016/j.yexmp.2008.03.007PMC PMC2595135
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Abstract

Strains of uropathogenic E. coli (UPEC) are the primary cause of urinary tract infections, including both cystitis and pyelonephritis. These bacteria have evolved a multitude of virulence factors and strategies that facilitate bacterial growth and persistence within the adverse settings of the host urinary tract. Expression of adhesive organelles like type 1 and P pili allow UPEC to bind and invade host cells and tissues within the urinary tract while expression of iron-chelating factors (siderophores) enable UPEC to pilfer host iron stores. Deployment of an array of toxins, including hemolysin and cytotoxic necrotizing factor 1, provide UPEC with the means to inflict extensive tissue damage, facilitating bacterial dissemination as well as releasing host nutrients and disabling immune effector cells. These toxins also have the capacity to modulate, in more subtle ways, host signaling pathways affecting myriad processes, including inflammatory responses, host cell survival, and cytoskeletal dynamics. Here, we discuss the mechanisms by which these and other virulence factors promote UPEC survival and growth within the urinary tract. Comparisons are also made between UPEC and other strains of extraintestinal pathogenic E. coli that, although closely related to UPEC, are distinct in their abilities to colonize the host and cause disease.

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  • MDR Escherichia coli infection is usually associated with urinary tract related infections and bacteremia.

    “MDR Escherichia coli infection is usually associated with urinary tract related infections and bacteremia [6–9].”

    From Multidrug-Resistant<i> Escherichia coli</i> Resulting in Postpartum Necrotizing Endomyometritis (2019) · cites this paper as [7]

    The Introduction identifies uropathogenic E. coli as a major cause of urinary tract infections and says extraintestinal pathogenic strains can colonize the blood. It does not establish that multidrug-resistant E. coli infections are usually associated with urinary tract infections and bacteremia; the resistance qualifier and usual association with bacteremia are unsupported. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Wiles, T. J., Kulesus, R. R., & Mulvey, M. A.
Affiliations
University of Utah (US)
Corresponding author
Mulvey, Matthew A.
ORCID
Venue
Experimental and Molecular Pathology
Publisher
Elsevier BV
Published
2008-08
Volume
85
Issue
1
Pages
11-19
ISSN
0014-4800 (ISSN-L)
DOI
10.1016/j.yexmp.2008.03.007
PMC
PMC2595135
OpenAlex
W2022178880
Cited by
606
References
5
Citations by year
2026: 23 · 2025: 20 · 2024: 24 · 2023: 31 · 2022: 35 · 2021: 43 · 2020: 26 · 2019: 40 · 2018: 35 · 2017: 37 · 2016: 38 · 2015: 46 · 2014: 33 · 2013: 40 · 2012: 36
FWCI
3.69
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental and Molecular Pathology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (T32AI055434)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK068585, R01DK068585)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
uropathogenic Escherichia coli, virulence factors, urinary tract infection, cystitis, pyelonephritis, type 1 fimbriae, P pili, siderophores, iron acquisition, hemolysin, cytotoxic necrotizing factor 1, host cell invasion, host-pathogen interaction, extraintestinal pathogenic Escherichia coli, bacterial colonization
MeSH terms
Escherichia coli, Humans, Urinary Tract Infections, Virulence, Virulence Factors

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