The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Tuning lipid mixtures to induce or suppress domain formation across leaflets of unsupported asymmetric bilayers
Open accessAbstract
Plasma membranes of cells are asymmetric in both lipid and protein composition. The mechanism by which proteins on both sides of the membrane colocalize during signaling events is unknown but may be due to the induction of inner leaflet domains by the outer leaflet. Here we show that liquid domains form in asymmetric Montal–Mueller planar bilayers in which one leaflet's composition would phase-separate in a symmetric bilayer and the other's would not. Equally important, by tuning the lipid composition of the second leaflet, we are able to suppress domains in the first leaflet. When domains are present in asymmetric membranes, each leaflet contains regions of three distinct lipid compositions, implying strong interleaflet interactions. Our results show that mechanisms of domain induction between the outer and inner leaflets of cell plasma membranes do not necessarily require the participation of membrane proteins. Based on these findings, we suggest mechanisms by which cells could actively regulate protein function by modulating local lipid composition or interleaflet interactions.
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Cites
Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Formation of Bimolecular Membranes from Lipid Monolayers and a Study of Their Electrical Properties
Montal, M., & Mueller, P. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.12.3561 · Cited by 1,787
Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension
Baumgart, T., Hess, S. T., & Webb, W. W. (2003) · Nature · doi:10.1038/nature02013 · Cited by 1,590
Lipid Rafts Reconstituted in Model Membranes
Dietrich, C., Bagatolli, L. A., Volovyk, Z. N., Thompson, N. L., Levi, M., Jacobson, K., & Gratton, E. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76114-0 · Cited by 1,376
Inside-outside transitions of phospholipids in vesicle membranes
McConnell, H. M., & Kornberg, R. D. (1971) · Biochemistry · doi:10.1021/bi00783a003 · Cited by 955
The differential adhesion hypothesis: a direct evaluation
Foty, R. A., & Steinberg, M. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.11.012 · Cited by 908
GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases
Štefanová, I., Hořejši, V., Ansotegui, I. J., Knapp, W., & Stockinger, H. (1991) · Science · doi:10.1126/science.1719635 · Cited by 826
Seeing spots: Complex phase behavior in simple membranes
Veatch, S. L., & Keller, S. L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.06.010 · Cited by 765
Self-citationAsymmetrical Lipid Bilayer Structure for Biological Membranes
BRETSCHER, M. S. (1972) · Nature New Biology · doi:10.1038/newbio236011a0 · Cited by 652
(1986) · Springer eBooks · doi:10.1007/978-1-4757-1361-9 · Cited by 602
Cited by
Revitalizing membrane rafts: new tools and insights
Simons, K., & Gerl, M. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2977 · Cited by 1,234
Lipid Organization of the Plasma Membrane
Ingólfsson, H. I., Melo, M. N., van Eerden, F. J., Arnarez, C., Lopez, C. A., Wassenaar, T. A., Periole, X., de Vries, A. H., Tieleman, D. P., & Marrink, S. J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja507832e · Cited by 931
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape
Lorent, J. H., Levental, K. R., Ganesan, L., Rivera-Longsworth, G., Sezgin, E., Doktorova, M., Lyman, E., & Levental, I. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0529-6 · Cited by 774
Nanoparticle-induced surface reconstruction of phospholipid membranes
Wang, B., Zhang, L., Bae, S. C., & Granick, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807296105 · Cited by 469
Critical Fluctuations in Plasma Membrane Vesicles
Veatch, S. L., Cicuta, P., Sengupta, P., Honerkamp-Smith, A., Holowka, D., & Baird, B. (2008) · ACS Chemical Biology · doi:10.1021/cb800012x · Cited by 468
Metadata
- Authors
- Collins, M. D., & Keller, S. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-01-08
- Volume
- 105
- Issue
- 1
- Pages
- 124-128
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979094684
- Cited by
- 272
- References
- 33
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- green
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