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Lipid rafts and signal transduction

Simons, Kai, Toomre, Derek·2000·Nature Reviews Molecular Cell Biology
DOI 10.1038/35036052
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Abstract

Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface -- known as lipid rafts -- also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades.

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Authors
Simons, K., & Toomre, D.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2000-10
Volume
1
Issue
1
Pages
31-39
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/35036052
Cited by
5,371
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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