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An Inhibitor of the Human UDP-GlcNAc 4-Epimerase Identified from a Uridine-Based Library

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Structure of UDP- N -acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide

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Cloning, expression and characterization of the pig liver GDP‐mannose pyrophosphorylase

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Oxidation and Transamination of the 3″-Position of UDP-N-Acetylglucosamine by Enzymes from Acidithiobacillus ferrooxidans

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Rapid Analysis of Large Protein–Protein Complexes Using NMR-derived Orientational Constraints: The 95kDa Complex of LpxA with Acyl Carrier Protein

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Expression Cloning of a Pseudomonas Gene Encoding a Hydroxydecanoyl-Acyl Carrier Protein-Dependent UDP-GlcNAc Acyltransferase

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The Conformational Change and Active Site Structure of Tetrahydrodipicolinate N-Succinyltransferase,

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Enzymatic Synthesis of Lipid A Molecules with Four Amide-linked Acyl Chains

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A Chlamydia trachomatisUDP-N-Acetylglucosamine Acyltransferase Selective for Myristoyl-Acyl Carrier Protein

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Nucleotide Substrate Recognition by UDP-N-acetylglucosamine Acyltransferase (LpxA) in the First Step of Lipid A Biosynthesis

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Intracellular Expression of Peptide Fusions for Demonstration of Protein Essentiality in Bacteria

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Crystallization of UDP‐N‐acetylglucosamine O‐acyltransferase from Escherichia coli

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Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

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Network-Based Metabolism-Centered Screening of Potential Drug Targets in Klebsiella pneumoniae at Genome Scale

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Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli

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Minor Modifications to the Phosphate Groups and the C3′ Acyl Chain Length of Lipid A in Two Bordetella pertussis Strains, BP338 and 18-323, Independently Affect Toll-like Receptor 4 Protein Activation

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Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis

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Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase

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Lipid A Biosynthesis of Multidrug-Resistant Pathogens - A Novel Drug Target

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Structural Basis for the Sugar Nucleotide and Acyl-Chain Selectivity of Leptospira interrogans LpxA

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Exploring the UDP pocket of LpxC through amino acid analogs

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Ecogenomics reveals viral communities across the Challenger Deep oceanic trench

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LpxI structures reveal how a lipid A precursor is synthesized

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Structural Basis for the Recognition of Peptide RJPXD33 by Acyltransferases in Lipid A Biosynthesis

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Taxol biosynthesis: Identification and characterization of two acetyl CoA:taxoid-O-acetyl transferases that divert pathway flux away from Taxol production

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Genetics and Biosynthesis of Lipopolysaccharide

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Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses

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Cellular Responses during Morphological Transformation in Azospirillum brasilense and Its flcA Knockout Mutant

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Structure determination of LpxA from the lipopolysaccharide-synthesis pathway ofAcinetobacter baumannii

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Structural and functional analysis of two universal stress proteins YdaA and YnaF from Salmonella typhimurium: possible roles in microbial stress tolerance

Bangera, M., Panigrahi, R. R., Sagurthi, S. R., Savithri, H. S., & Murthy, M. R. N. (2015) · Journal of Structural Biology · doi:10.1016/j.jsb.2015.01.003 · Cited by 18 · see citing works

Structural Basis of Acyl-Carrier Protein Interactions in Fatty Acid and Polyketide Biosynthesis

Mindrebo, J. T., Patel, A., Misson, L., Kim, W. E., Davis, T. D., Ni, Q. Z., Clair, J. J. L., & Burkart, M. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14662-1 · Cited by 18 · see citing works

Identification of Three Genes Encoding for the Late Acyltransferases of Lipid A in Cronobacter sakazakii

Cai, L., Li, Y., Tao, G., Guo, W., Zhang, C., & Wang, X. (2013) · Marine Drugs · doi:10.3390/md11020377 · Cited by 16 · see citing works

New virulence factor CSK29544_02616 as LpxA binding partner in Cronobacter sakazakii

Kim, S., Yoon, H., & Ryu, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19306-0 · Cited by 15 · see citing works

Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors

John, C. M., Feng, D., & Jarvis, G. A. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky151 · Cited by 15 · see citing works

Structure-Based Virtual Screening of Pseudomonas aeruginosa LpxA Inhibitors using Pharmacophore-Based Approach

Bhaskar, B. V., Tirumalasetty, M. B., Rammohan, A., Zheng, G. Y., Zyryanov, G. V., & Gu, W. (2020) · Biomolecules · doi:10.3390/biom10020266 · Cited by 13 · see citing works

Theoretical study of lipid biosynthesis in wild‐type Escherichia coli and in a protoplast‐type L‐form using elementary flux mode analysis

Kenanov, D., Kaleta, C., Petzold, A., Hoischen, C., Diekmann, S., Siddiqui, R. A., & Schuster, S. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07546.x · Cited by 13 · see citing works

Decoding a Gut Commensal Signal: Structural and Immunological Profiling of Segatella Copri Lipopolysaccharide

Carone, L. D. S., Barra, G., Cirella, R., Ziaco, M., Mercogliano, M., Olmeo, F., Andretta, E., Mazziotti, V., Fusco, C., d’Ippolito, G., et al. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202512947 · Cited by 14 · see citing works

Acyl chain preference and inhibitor identification of Moraxella catarrhalis LpxA: Insight through crystal structure and computational studies

Pratap, S., Kesari, P., Yadav, R., Dev, A., Narwal, M., & Kumar, P. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.01.005 · Cited by 12 · see citing works

Formation of Fatty Acids

López-Lara, I. M., & Geiger, O. (2009) · Springer eBooks · doi:10.1007/978-3-540-77587-4_26 · Cited by 12 · see citing works

Crystal structure and functional implications of the tandem-type universal stress protein UspE from Escherichia coli

Xu, Y., Guo, J., Jin, X., Kim, J., Ji, Y., Fan, S., Ha, N., & Quan, C. (2016) · BMC Structural Biology · doi:10.1186/s12900-016-0053-9 · Cited by 11 · see citing works

Cj1123c (PglD), a multifaceted acetyltransferase from Campylobacter jejuni

Demendi, M., & Creuzenet, C. (2009) · Biochemistry and Cell Biology · doi:10.1139/o09-002 · Cited by 11 · see citing works

Activity and Crystal Structure of Arabidopsis thalianaUDP-N-Acetylglucosamine Acyltransferase

Joo, S. H., Chung, H. S., Raetz, C. R. H., & Garrett, T. A. (2012) · Biochemistry · doi:10.1021/bi3002242 · Cited by 11 · see citing works

Identification and prioritization of potential therapeutic molecules against LpxA from Acinetobacter baumannii – A computational study

Khan, R. J., Singh, E., Jha, R. K., Kumar, A., Bhati, S. K., Zia, M. P., Jain, M., Singh, R. P., Muthukumaran, J., & Singh, A. K. (2023) · Current Research in Structural Biology · doi:10.1016/j.crstbi.2023.100096 · Cited by 10 · see citing works

Site-Directed Mutagenesis Demonstrates the Plasticity of the β Helix: Implications for the Structure of the Misfolded Prion Protein

Choi, J. H., May, B. C. H., Govaerts, C., & Cohen, F. E. (2009) · Structure · doi:10.1016/j.str.2009.05.013 · Cited by 9 · see citing works

LipidA-IDER to Explore the Global Lipid A Repertoire of Drug-Resistant Gram-Negative Bacteria

Guan, X. L., Loh, J., Lizwan, M., Chan, S. C. M., Kwan, J. M. C., Lim, T.-P., Koh, T. H., Hsu, L. Y., & Lee, B. T. K. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03566 · Cited by 7 · see citing works

Formation of Fatty Acids

López-Lara, I. M., & Geiger, O. (2018) · Springer eBooks · doi:10.1007/978-3-319-43676-0_5-1 · Cited by 7 · see citing works

The Inhibition of Lipid A Biosynthesis—The Antidote Against Superbugs?

González‐Bello, C. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800117 · Cited by 7 · see citing works

Conditional lethality and suppressor analysis of plasmid-based temperature-sensitive fabZ expression in Pseudomonas aeruginosa

Chen, Z., Lu, J., Tang, Q., & Yang, Z. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108553 · Cited by 6 · see citing works

Signaling through the Salmonella PbgA-LapB regulatory complex activates LpxC proteolysis and limits lipopolysaccharide biogenesis during stationary-phase growth

Mettlach, J. A., Cian, M. B., Chakraborty, M., & Dalebroux, Z. D. (2024) · Journal of Bacteriology · doi:10.1128/jb.00308-23 · Cited by 5 · see citing works

Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action

Ostroumova, O. S., & Efimova, S. S. (2023) · Antibiotics · doi:10.3390/antibiotics12121716 · Cited by 6 · see citing works

The role of the essential GTPase ObgE in regulating lipopolysaccharide synthesis in Escherichia coli

Dewachter, L., Deckers, B., Mares-Mejía, I., Louwagie, E., Vercauteren, S., Matthay, P., Brückner, S., Möller, A.-M., Narberhaus, F., Vonesch, S. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53980-1 · Cited by 7 · see citing works

Differential membrane lipid disruption by lipopeptide antibiotics, colistin and turnercyclamycins

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Review on Current Research on Biosynthesis of Biosurfactants and the Regulation Influenced by Metal Ions

Wang, Y., Qiao, S., & Niu, Y. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2503.03031 · Cited by 4 · see citing works

Formation of Fatty Acids

López-Lara, I. M., & Geiger, O. (2019) · Springer eBooks · doi:10.1007/978-3-319-50430-8_5 · Cited by 4 · see citing works

Rational design of inhibitors against LpxA protein of Acinetobacter baumannii using a virtual screening method

Fereshteh, S., Kalhor, H., Sepehr, A., Rahimi, H., Zafari, M., Cohan, R. A., & Badmasti, F. (2021) · Journal of the Indian Chemical Society · doi:10.1016/j.jics.2021.100319 · Cited by 4 · see citing works

Uncovering lipopolysaccharide regulation in bacteria via the critical lipid binding tunnel of YciS/YciM

Yan, L., Dong, H., Li, H. Z., Liu, X., Deng, Z., Dong, C., & Zhang, Z. (2022) · iScience · doi:10.1016/j.isci.2022.104988 · Cited by 3 · see citing works

The fatty acid synthesis gene fabY affects lipopolysaccharide synthesis and colistin susceptibility in Pseudomonas aeruginosa

Zhou, D.-D., Wei, X., Jin, Y., Cheng, Z., Jin, S., Ha, U., Pan, X., & Wu, W. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01339-25 · Cited by 2 · see citing works

Profile of Christian R. H. Raetz

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Characterization of left‐handed beta helix‐domains, and identification and functional annotation of proteins containing such domains

Prabha, A., & Balaji, P. V. (2020) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.25990 · Cited by 2 · see citing works

Genetics and Biosynthesis of Lipid A

Stead, C. M., Pride, A. C., & Trent, M. S. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0733-1_6 · Cited by 2 · see citing works

Crystal structure and activity of Francisella novicida UDP-N-acetylglucosamine acyltransferase

Joo, S. H., & Chung, H. S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.098 · Cited by 2 · see citing works

A dedicated C-6 β-hydroxyacyltransferase required for biosynthesis of the glycolipid anchor for Vi antigen capsule in typhoidal Salmonella

Liston, S. D., Ovchinnikova, O. G., Kimber, M. S., & Whitfield, C. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102520 · Cited by 1 · see citing works

Reliable Chemical Synthesis of UDP-3-O-[(R)-3-Hydroxydecanoyl]-GlcNAc: The Native Substrate of Pseudomonas aeruginosa LpxC

Wei, J., Fan, Y., Kuang, B., Zhu, X., Zhang, X., & Zhu, Y. (2024) · Organic Letters · doi:10.1021/acs.orglett.4c04042 · Cited by 1 · see citing works

Evaluating Natural Compounds as Inhibitors of Lipopolysaccharide Biosynthesis in Acinetobacter baumannii: A Comprehensive Method Employing Molecular Docking and Dynamics Simulations

Haryini, S., Rais, A., Gopikrishnan, M., Elavarasu, S. M., Kumar, D. T., Sasikumar, K., & Doss, C. G. P. (2024) · Journal of Computational Biophysics and Chemistry · doi:10.1142/s2737416524500893 · Cited by 1 · see citing works

Extraction and bioinformatics analysis of Chlamydia trachomatis LpxA

Li, D., Feng, H.-H., Mu, Y.-T., Yu, J., & Yang, F. (2020) · International Ophthalmology · doi:10.1007/s10792-020-01623-x · Cited by 1 · see citing works

Biosynthesis and membrane assembly of lipid A

Trent, M. S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374546-0.00017-1

26 Formation of Fatty Acids

Geiger, O. (2010)

Immunomodulation by bacteriophages

Belleghem, J. D. V. (2017) · Ghent University Academic Bibliography (Ghent University)

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesisPreprint

Han, W., Ma, X., Balibar, C. J., Rath, C. M. B., Benton, B. M., Bermingham, A., Casey, F., Chie-Leon, B., Cho, M., Frank, A. O., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.14.850305

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesisPreprint

Han, W., Ma, X., Balibar, C. J., Rath, C. M. B., Benton, B. M., Bermingham, A., Casey, F., Chie-Leon, B., Cho, M., Frank, A. O., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/850305

Decoding a Gut Commensal Signal: Structural and Immunological Profiling of Segatella Copri Lipopolysaccharide

Carone, L. D. S., Barra, G., Cirella, R., Ziaco, M., Mercogliano, M., Olmeo, F., Andretta, E., Mazziotti, V., Fusco, C., d’Ippolito, G., et al. (2025) · Angewandte Chemie · doi:10.1002/ange.202512947

Les endotoxines du genre Bordetella : structure, évolution et impact sur la virulence bactérienne

Albitar‐Nehme, S. (2014) · doi:10.70675/43637f20z4d9fz4749za9c1z877d9319e172

BindingDB Entry 50005320: Exploring the UDP pocket of LpxC through amino acid analogs.

BindingDB (2020) · UC San Diego · doi:10.7270/q2f76ggd

BindingDB Entry 50012156: N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.

BindingDB (2022) · UC San Diego · doi:10.7270/q2c2513c

BindingDB Entry 8018: Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis.

BindingDB (2017) · UC San Diego · doi:10.7270/q2rv0mjp

BindingDB Entry 50020010: Antibacterial activities of anthraquinones: structure-activity relationships and action mechanisms.

BindingDB (2024) · UC San Diego · doi:10.7270/q2pc36t0

BindingDB Entry 50017360: Chemical Highlights Supporting the Role of Lipid A in Efficient Biological Adaptation of Gram-Negative Bacteria to External Stresses.

BindingDB (2023) · UC San Diego · doi:10.7270/q2tf02dr

Structural Basis for the Sugar Nucleotide and Acyl-Chain Selectivity of Leptospira interrogans LpxA

Robins, L. I., Williams, A. H., & Raetz, C. R. H. (2009) · Biochemistry · doi:10.1021/bi900629e · Cited by 30 · see citing works

Structures of Pseudomonas aeruginosa LpxA Reveal the Basis for Its Substrate Selectivity

Smith, E. W., Zhang, X., Behzadi, C., Andrews, L. D., Cohen, F., & Chen, Y. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00720 · Cited by 28 · see citing works

Nucleotide Substrate Recognition by UDP-N-acetylglucosamine Acyltransferase (LpxA) in the First Step of Lipid A Biosynthesis

Ulaganathan, V., Buetow, L., & Hunter, W. N. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.03.039 · Cited by 32 · see citing works

Structure of UDP‐N‐acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide

Williams, A. H., Immormino, R. M., Gewirth, D. T., & Raetz, C. R. H. (2006) · The FASEB Journal · doi:10.1096/fasebj.20.5.a953 · Cited by 2 · see citing works

Crystal Structure and Acyl Chain Selectivity of Escherichia coli LpxD, the N-Acyltransferase of Lipid A Biosynthesis

Bartling, C. M., & Raetz, C. R. H. (2009) · Biochemistry · doi:10.1021/bi901025v · Cited by 56 · see citing works