The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents
Open accessAbstract
A cell delivery strategy was investigated that was hypothesized to enable magnetic targeting of endothelial cells to the steel surfaces of intraarterial stents because of the following mechanisms: (i) preloading cells with biodegradable polymeric superparamagnetic nanoparticles (MNPs), thereby rendering the cells magnetically responsive; and (ii) the induction of both magnetic field gradients around the wires of a steel stent and magnetic moments within MNPs because of a uniform external magnetic field, thereby targeting MNP-laden cells to the stent wires. In vitro studies demonstrated that MNP-loaded bovine aortic endothelial cells (BAECs) could be magnetically targeted to steel stent wires. In vivo MNP-loaded BAECs transduced with adenoviruses expressing luciferase (Luc) were targeted to stents deployed in rat carotid arteries in the presence of a uniform magnetic field with significantly greater Luc expression, detected by in vivo optical imaging, than nonmagnetic controls.
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“Studies investigating the biological effects of (typically sugar-coated) SPION on dendritic cells [126], mesenchymal stem cells [127, 128], endothelial cells [129, 130] and tumor cells [131] have reported no impact on phenotype and cellular function.”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [130]
In the citing paper
“Polyak et al.102 used an alternative method to address delayed endothelial healing. Rats with stainless steel stents in their carotid arteries were intra-arterially injected with superparamagnetic nanoparticles that were preloaded into endothelial cells, making these cells magnetically responsive. The rats were subsequently exposed to a homogenous magnetic field that showed a high uptake of cells”
From Perspectives and opportunities for nanomedicine in the management of atherosclerosis (2011) · cites this paper as [102]
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Metadata
- Authors
- Polyak, B., Fishbein, I., Chorny, M., Alferiev, I., Williams, D., Yellen, B., Friedman, G., & Levy, R. J.
- Affiliations
- Drexel University (US)
- Children's Hospital of Philadelphia (US)
- Duke University (US)
- Corresponding author
- Levy, Robert J.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2008-01-15
- Volume
- 105
- Issue
- 2
- Pages
- 698-703
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2206599
- OpenAlex
- W2169410023
- Cited by
- 257
- References
- 28
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 6 · 2019: 19 · 2018: 16 · 2017: 11 · 2016: 18 · 2015: 18 · 2014: 21 · 2013: 20 · 2012: 29
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Children's Hospital of Philadelphia
- National Institutes of Health (HL72108)
- National Heart, Lung, and Blood Institute (HL72108, R56HL072108, R01HL072108)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- magnetic cell targeting, superparamagnetic iron oxide nanoparticles, endothelial cells, magnetic field gradient, cell delivery, biodegradable polymer nanoparticles, adenoviral gene transfer, luciferase expression, carotid artery stenting, in vivo optical imaging
- MeSH terms
- Animals, Aorta, Biocompatible Materials, Carotid Arteries, Cattle, Magnetics, Male, Models, Biological, Polymers, Steel, Genetic Therapy, Stents, Rats, Sprague-Dawley, Nanotechnology, Endothelial Cells, Rats, Metal Nanoparticles, Cell- and Tissue-Based Therapy
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