Cited by 257Characterization and Applications of Magnetic NanoparticlesNanoparticle-Based Drug DeliveryMesenchymal stem cell research

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High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents

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Polyak, Boris, Fishbein, Ilia, Chorny, Michael, Alferiev, Ivan, Williams, Darryl, Yellen, Ben, Friedman, Gary, Levy, Robert J.·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0708338105PMC PMC2206599

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Abstract

A cell delivery strategy was investigated that was hypothesized to enable magnetic targeting of endothelial cells to the steel surfaces of intraarterial stents because of the following mechanisms: (i) preloading cells with biodegradable polymeric superparamagnetic nanoparticles (MNPs), thereby rendering the cells magnetically responsive; and (ii) the induction of both magnetic field gradients around the wires of a steel stent and magnetic moments within MNPs because of a uniform external magnetic field, thereby targeting MNP-laden cells to the stent wires. In vitro studies demonstrated that MNP-loaded bovine aortic endothelial cells (BAECs) could be magnetically targeted to steel stent wires. In vivo MNP-loaded BAECs transduced with adenoviruses expressing luciferase (Luc) were targeted to stents deployed in rat carotid arteries in the presence of a uniform magnetic field with significantly greater Luc expression, detected by in vivo optical imaging, than nonmagnetic controls.

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Authors: Polyak, B., Fishbein, I., Chorny, M., Alferiev, I., Williams, D., Yellen, B., Friedman, G., & Levy, R. J.
Affiliations: Drexel University (US)
Children's Hospital of Philadelphia (US)
Duke University (US)
Corresponding author: Levy, Robert J.
ORCID: Polyak, Boris
Fishbein, Ilia
Chorny, Michael
Alferiev, Ivan
Levy, Robert J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2008-01-15
Volume: 105
Issue: 2
Pages: 698-703
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0708338105
PMC: PMC2206599
OpenAlex: W2169410023
Cited by: 257
References: 28
Citations by year: 2026: 4 · 2025: 7 · 2024: 6 · 2023: 8 · 2022: 6 · 2021: 13 · 2020: 6 · 2019: 19 · 2018: 16 · 2017: 11 · 2016: 18 · 2015: 18 · 2014: 21 · 2013: 20 · 2012: 29
FWCI: 12.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Children's Hospital of Philadelphia
National Institutes of Health (HL72108)
National Heart, Lung, and Blood Institute (HL72108, R56HL072108, R01HL072108)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: magnetic cell targeting, superparamagnetic iron oxide nanoparticles, endothelial cells, magnetic field gradient, cell delivery, biodegradable polymer nanoparticles, adenoviral gene transfer, luciferase expression, carotid artery stenting, in vivo optical imaging
MeSH terms: Animals, Aorta, Biocompatible Materials, Carotid Arteries, Cattle, Magnetics, Male, Models, Biological, Polymers, Steel, Genetic Therapy, Stents, Rats, Sprague-Dawley, Nanotechnology, Endothelial Cells, Rats, Metal Nanoparticles, Cell- and Tissue-Based Therapy

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High field gradient targeting of magnetic nanoparticle-loaded endothelial cells to the surfaces of steel stents

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