The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Variation in HIV-1 set-point viral load: Epidemiological analysis and an evolutionary hypothesis
Open accessAbstract
The natural course of HIV-1 infection is characterized by a high degree of heterogeneity in viral load, not just within patients over time, but also between patients, especially during the asymptomatic stage of infection. Asymptomatic, or set-point, viral load has been shown to correlate with both decreased time to AIDS and increased infectiousness. The aim of this study is to characterize the epidemiological impact of heterogeneity in set-point viral load. By analyzing two cohorts of untreated patients, we quantify the relationships between both viral load and infectiousness and the duration of the asymptomatic infectious period. We find that, because both the duration of infection and infectiousness determine the opportunities for the virus to be transmitted, this suggests a trade-off between these contributions to the overall transmission potential. Some public health implications of variation in set-point viral load are discussed. We observe that set-point viral loads are clustered around those that maximize the transmission potential, and this leads us to hypothesize that HIV-1 could have evolved to optimize its transmissibility, a form of adaptation to the human host population. We discuss how this evolutionary hypothesis can be tested, review the evidence available to date, and highlight directions for future research.
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Cites
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Cited by
Multiple scales of selection influence the evolutionary emergence of novel pathogens
Park, M., Loverdo, C., Schreiber, S. J., & Lloyd-Smith, J. O. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0333 · Cited by 51
Metadata
- Authors
- Fraser, C., Hollingsworth, T. D., Chapman, R., de Wolf, F., & Hanage, W. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2007-10-30
- Volume
- 104
- Issue
- 44
- Pages
- 17441-17446
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2070649137
- Cited by
- 438
- References
- 26
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fraser, C., Hollingsworth, T. D., Chapman, R., de Wolf, F., & Hanage, W. P. (2007). Variation in HIV-1 set-point viral load: Epidemiological analysis and an evolutionary hypothesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0708559104
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
