The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Cell-specific nitrogen responses mediate developmental plasticity
Open accessAbstract
The organs of multicellular species consist of cell types that must function together to perform specific tasks. One critical organ function is responding to internal or external change. Some cell-specific responses to changes in environmental conditions are known, but the scale of cell-specific responses within an entire organ as it perceives an environmental flux has not been well characterized in plants or any other multicellular organism. Here, we use cellular profiling of five Arabidopsis root cell types in response to an influx of a critical resource, nitrogen, to uncover a vast and predominantly cell-specific response. We show that cell-specific profiling increases sensitivity several-fold, revealing highly localized regulation of transcripts that were largely hidden from previous global analyses. The cell-specific data revealed responses that suggested a coordinated developmental response in distinct cell types or tissues. One example is the cell-specific regulation of a transcriptional circuit that we showed mediates lateral root outgrowth in response to nitrogen via microRNA167, linking small RNAs to nitrogen responses. Together, these results reveal a previously cryptic component of cell-specific responses to nitrogen. Thus, the results make an important advance in our understanding of how multicellular organisms cope with environmental change at the cell level.
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Cites
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F., Ben Miled, S., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,803
Significance analysis of microarrays applied to the ionizing radiation response
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The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
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A Gene Expression Map of the Arabidopsis Root
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Self-citationOrganization and cell differentiation in lateral roots of Arabidopsis thaliana
Malamy, J. E., & Benfey, P. N. (1997) · Development · doi:10.1242/dev.124.1.33 · Cited by 1,258
The PLETHORA Genes Mediate Patterning of the Arabidopsis Root Stem Cell Niche
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PHO2, MicroRNA399, and PHR1 Define a Phosphate-Signaling Pathway in Plants
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Cited by
Plant Nitrogen Assimilation and Use Efficiency
Xu, G., Fan, X., & Miller, A. J. (2012) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105532 · Cited by 2,114
Ruffel, S., Krouk, G., Ristova, D., Shasha, D., Birnbaum, K. D., & Coruzzi, G. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108684108 · Cited by 401
Self-citationNitrate in 2020: Thirty Years from Transport to Signaling Networks
Vidal, E. A., Alvarez, J. M., Araus, V., Riveras, E., Brooks, M. D., Krouk, G., Ruffel, S., Lejay, L., Crawford, N. M., Coruzzi, G. M., et al. (2020) · The Plant Cell · doi:10.1105/tpc.19.00748 · Cited by 382
Self-citationGene expression map of the Arabidopsis shoot apical meristem stem cell niche
Yadav, R. K., Girke, T., Pasala, S., Xie, M., & Reddy, G. V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900843106 · Cited by 337
Learning from Co-expression Networks: Possibilities and Challenges
Serin, E. A. R., Nijveen, H., Hilhorst, H. W. M., & Ligterink, W. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00444 · Cited by 304
Metadata
- Authors
- Gifford, M. L., Dean, A., Gutierrez, R. A., Coruzzi, G. M., & Birnbaum, K. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-01-15
- Volume
- 105
- Issue
- 2
- Pages
- 803-808
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2015936510
- Cited by
- 615
- References
- 27
- FWCI
- 39.72
- Type
- journal article
- Language
- en
- Open access
- green
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