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Cited by 401

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Nitrogen economics of root foraging: Transitive closure of the nitrate–cytokinin relay and distinct systemic signaling for N supply vs. demand

Open access
Ruffel, Sandrine, Krouk, Gabriel, Ristova, Daniela, Shasha, Dennis, Birnbaum, Kenneth D., Coruzzi, Gloria M.·2011·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1108684108
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Abstract

As sessile organisms, root plasticity enables plants to forage for and acquire nutrients in a fluctuating underground environment. Here, we use genetic and genomic approaches in a “split-root” framework—in which physically isolated root systems of the same plant are challenged with different nitrogen (N) environments—to investigate how systemic signaling affects genome-wide reprogramming and root development. The integration of transcriptome and root phenotypes enables us to identify distinct mechanisms underlying “N economy” (i.e., N supply and demand) of plants as a system. Under nitrate-limited conditions, plant roots adopt an “active-foraging strategy”, characterized by lateral root outgrowth and a shared pattern of transcriptome reprogramming, in response to either local or distal nitrate deprivation. By contrast, in nitrate-replete conditions, plant roots adopt a “dormant strategy”, characterized by a repression of lateral root outgrowth and a shared pattern of transcriptome reprogramming, in response to either local or distal nitrate supply. Sentinel genes responding to systemic N signaling identified by genome-wide comparisons of heterogeneous vs. homogeneous split-root N treatments were used to probe systemic N responses in Arabidopsis mutants impaired in nitrate reduction and hormone synthesis and also in decapitated plants. This combined analysis identified genetically distinct systemic signaling underlying plant N economy: ( i ) N supply, corresponding to a long-distance systemic signaling triggered by nitrate sensing; and ( ii ) N demand, experimental support for the transitive closure of a previously inferred nitrate–cytokinin shoot–root relay system that reports the nitrate demand of the whole plant, promoting a compensatory root growth in nitrate-rich patches of heterogeneous soil.

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Metadata

Authors
Ruffel, S., Krouk, G., Ristova, D., Shasha, D., Birnbaum, K. D., & Coruzzi, G. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2011-10-24
Volume
108
Issue
45
Pages
18524-18529
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1108684108
OpenAlex
W2104388974
Cited by
401
References
41
FWCI
25.43
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Nitrogen economics of root foraging: Transitive closure of the nitrate–cytokinin relay and distinct systemic signaling for N supply vs. demand. https://app.cochat.ai/papers/10.1073/pnas.1108684108
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Ruffel, S., Krouk, G., Ristova, D., Shasha, D., Birnbaum, K. D., & Coruzzi, G. M. (2011). Nitrogen economics of root foraging: Transitive closure of the nitrate–cytokinin relay and distinct systemic signaling for N supply vs. demand. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1108684108

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.