Cited by 174Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated ReceptorsCancer, Lipids, and Metabolism

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Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR

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Schug, Thaddeus T., Berry, Daniel C., Toshkov, Illia A., Cheng, Le, Nikitin, Alexander Yu, Noy, Noa·2008·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0709981105PMC PMC2396692

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Abstract

Retinoic acid (RA) displays potent anticarcinogenic activities that are mediated by the nuclear retinoic acid receptors (RARs). However, use of RA in oncology is limited by RA resistance acquired during carcinogenesis. Moreover, in some cancers, RA facilitates rather than inhibits growth. A clue to this paradoxical behavior was recently suggested by the findings that RA also activates PPARβ/δ, a receptor involved in mitogenic and anti-apoptotic activities. The observations that partitioning of RA between its two receptors is regulated by two intracellular lipid-binding proteins—CRABP-II, which targets RA to RAR, and FABP5, which delivers it to PPARβ/δ—further suggest that RA resistance may stem from the deregulation of the binding proteins, resulting in activation of PPARβ/δ rather than RAR. Here, we show that, in the RA-resistant mouse model of breast cancer MMTV-neu , RA indeed activates the nonclassical RA receptor PPARβ/δ. This behavior was traced to an aberrantly high intratumor FABP5/CRABP-II ratio. Decreasing this ratio in mammary tissue diverted RA from PPARβ/δ to RAR and suppressed tumor growth. The data demonstrate the existence of a mechanism that underlies RA resistance in tumors, indicate that CRABP-II functions as a tumor suppressor, and suggest that the inhibition of FABP5 may comprise a therapeutic strategy for overcoming RA resistance in some tumors.

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Authors: Schug, T. T., Berry, D. C., Toshkov, I. A., Cheng, L., Nikitin, A. Y., & Noy, N.
Affiliations: Cornell University (US)
Case Western Reserve University (US)
ORCID: Berry, Daniel C.
Nikitin, Alexander Yu
Noy, Noa
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2008-05-27
Volume: 105
Issue: 21
Pages: 7546-7551
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0709981105
PMC: PMC2396692
OpenAlex: W2093995222
Cited by: 172
References: 45
Citations by year: 2026: 1 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 10 · 2017: 12 · 2016: 12 · 2015: 15 · 2014: 15 · 2013: 10 · 2012: 7
FWCI: 5.35
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (CA107013)
National Cancer Institute (R01CA096823, R01 CA 96823, R01CA107013, T32CA009682)
National Center for Research Resources (CA96823, K26RR017595)
Institute of Genetics
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: retinoic acid resistance, PPARδ, retinoic acid receptor, breast cancer, FABP5, CRABP2, lipid-binding proteins, tumor suppressor, retinoic acid signaling, breast cancer treatment
MeSH terms: Animals, Antineoplastic Agents, Carcinoma, Disease Models, Animal, Mice, Transgenic, Neoplasm Proteins, Transcription, Genetic, Tretinoin, Mammary Neoplasms, Animal, Receptors, Retinoic Acid, Drug Resistance, Neoplasm, Cell Line, Tumor, PPAR delta, PPAR-beta, Fatty Acid-Binding Proteins, Mice

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Overcoming retinoic acid-resistance of mammary carcinomas by diverting retinoic acid from PPARβ/δ to RAR

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