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Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene
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Fasting induces ANGPTL4 expression in tissues other than adipose, including liver and some oxidative tissues.
“fasting induces ANGPTL4 expression in tissues other than adipose, including liver and some oxidative tissues (40, 46, 47, 72).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [46]
Angptl4 is a known inhibitor of LPL activity in peripheral tissues.
“Angiopoietin-like (Angptl) 4 is a known inhibitor of LPL activity.”
From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [4]
Angptl4 is primarily expressed in adipose tissue and liver, induced by fasting and secreted into the circulation.
“Angptl4 is primarily expressed in adipose tissue and liver, induced by fasting and secreted into the circulation [4], where it prevents LPL dimerization and thereby preventing LPL activation [5–8].”
From Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity (2015) · cites this paper as [4]
Fasting induced liver expression of FIAF.
“They also found that fasting induced liver expression of FIAF.”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [46]
Angptl4 is expressed in several tissues including liver, heart, intestine, and skeletal muscle.
“Although Angptl4 is most highly expressed in adipose, it is also expressed in several other tissues including liver, heart, intestine, and skeletal muscle (40, 46, 47, 72).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [46]
Angptl4 is highly expressed in adipose tissue and expression in adipose is quickly induced by fasting.
“Angptl4 is highly expressed in adipose tissue (46, 47) and expression in adipose is quickly induced by fasting (16, 46, 62, 63).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [46]
ANGPTL4 was discovered as a secreted PPAR target gene expressed highly in adipose tissue.
“In 2000, two groups described the discovery of a secreted PPAR target gene expressed highly in adipose tissue (46, 47).”
From Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8 (2021) · cites this paper as [46]
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Metadata
- Authors
- Kersten, S., Mandard, S., Tan, N. S., Escher, P., Metzger, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-09
- Volume
- 275
- Issue
- 37
- Pages
- 28488-28493
- ISSN
- 0021-9258
- Cited by
- 489
- References
- 2
- Language
- en
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