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Cited by 189

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Evolution of polyketide synthases in bacteria

Open access
Ridley, Christian P., Lee, Ho Young, Khosla, Chaitan·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0710107105
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Abstract

The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature. Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabilities can guide future laboratory efforts in generating the next generation of polyketide antibiotics. Here, we examine phylogenetic and structural evidence to glean answers to two general questions regarding PKS evolution. How did the exceptionally diverse chemistry of present-day PKSs evolve? And what are the take-home messages for the biosynthetic engineer?

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Metadata

Authors
Ridley, C. P., Lee, H. Y., & Khosla, C.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2008-03-25
Volume
105
Issue
12
Pages
4595-4600
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0710107105
OpenAlex
W2008133665
Cited by
189
References
0
FWCI
6.62
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Evolution of polyketide synthases in bacteria. https://app.cochat.ai/papers/10.1073/pnas.0710107105
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Ridley, C. P., Lee, H. Y., & Khosla, C. (2008). Evolution of polyketide synthases in bacteria. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0710107105

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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