Modulation of gut microbiota dysbioses in type 2 diabetic patients by macrobiotic Ma-Pi 2 diet
Open accessAbstract
The gut microbiota exerts a role in type 2 diabetes (T2D), and deviations from a mutualistic ecosystem layout are considered a key environmental factor contributing to the disease. Thus, the possibility of improving metabolic control in T2D by correcting gut microbiome dysbioses through diet has been evaluated. Here, we explore the potential of two different energy-restricted dietary approaches - the fibre-rich macrobiotic Ma-Pi 2 diet or a control diet recommended by Italian professional societies for T2D treatment - to correct gut microbiota dysbioses in T2D patients. In a previous 21-d open-label MADIAB trial, fifty-six overweight T2D patients were randomised to the Ma-Pi 2 or the control diet. For the present study, stools were collected before and after intervention from a subset of forty MADIAB participants, allowing us to characterise the gut microbiota by 16S rRNA sequencing and imputed metagenomics. To highlight microbiota dysbioses in T2D, the gut microbiota of thirteen normal-weight healthy controls were characterised. According to our findings, both diets were effective in modulating gut microbiome dysbioses in T2D, resulting in an increase of the ecosystem diversity and supporting the recovery of a balanced community of health-promoting SCFA producers, such as Faecalibacterium, Roseburia, Lachnospira, Bacteroides and Akkermansia. The Ma-Pi 2 diet, but not the control diet, was also effective in counteracting the increase of possible pro-inflammatory groups, such as Collinsella and Streptococcus, in the gut ecosystem, showing the potential to reverse pro-inflammatory dysbioses in T2D, and possibly explaining the greater efficacy in improving the metabolic control.
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Several studies of different diets associated weight loss with enrichment of Akkermansia muciniphila.
“Several studies of different diets associated weight loss with enrichment of A muciniphila.86, 93, 98, 99”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [98]
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Self-citation
- Authors
- Candela, M., Biagi, E., Soverini, M., Consolandi, C., Quercia, S., Severgnini, M., Peano, C., Turroni, S., Rampelli, S., Pozzilli, P., Pianesi, M., Fallucca, F., & Brigidi, P.
- Affiliations
- University of Bologna (IT)
- Institute of Biomedical Technologies (IT)
- Università Campus Bio-Medico (IT)
- Sapienza University of Rome (IT)
- Corresponding author
- Candela, Marco
- ORCID
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-05-06
- Volume
- 116
- Issue
- 1
- Pages
- 80-93
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- PMC
- PMC4894062
- OpenAlex
- W2345810007
- Cited by
- 260
- References
- 59
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 24 · 2023: 43 · 2022: 36 · 2021: 52 · 2020: 27 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 4
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- type 2 diabetes, gut microbiota, dysbiosis, macrobiotic diet, caloric restriction, dietary intervention, short-chain fatty acids, Faecalibacterium, Akkermansia, Collinsella, Streptococcus, pro-inflammatory bacteria, metabolic control, overweight patients
- MeSH terms
- Adult, Aged, Bacteria, Diabetes Mellitus, Type 2, Female, Humans, Intestines, Male, Middle Aged, Diet, Macrobiotic, Overweight, Young Adult, Microbiota
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