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Free energy reconstruction from nonequilibrium single-molecule pulling experiments
Open accessAbstract
Laser tweezers and atomic force microscopes are increasingly used to probe the interactions and mechanical properties of individual molecules. Unfortunately, using such time-dependent perturbations to force rare molecular events also drives the system away from equilibrium. Nevertheless, we show how equilibrium free energy profiles can be extracted rigorously from repeated nonequilibrium force measurements on the basis of an extension of Jarzynski's remarkable identity between free energies and the irreversible work.
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Metadata
- Authors
- Hummer, G., & Szabo, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-03-27
- Volume
- 98
- Issue
- 7
- Pages
- 3658-3661
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2102375526
- Cited by
- 983
- References
- 0
- FWCI
- 18.34
- Type
- journal article
- Language
- en
- Open access
- green
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