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Noninvasive molecular imaging of small living subjects using Raman spectroscopy
Open accessAbstract
Molecular imaging of living subjects continues to rapidly evolve with bioluminescence and fluorescence strategies, in particular being frequently used for small-animal models. This article presents noninvasive deep-tissue molecular images in a living subject with the use of Raman spectroscopy. We describe a strategy for small-animal optical imaging based on Raman spectroscopy and Raman nanoparticles. Surface-enhanced Raman scattering nanoparticles and single-wall carbon nanotubes were used to demonstrate whole-body Raman imaging, nanoparticle pharmacokinetics, multiplexing, and in vivo tumor targeting, using an imaging system adapted for small-animal Raman imaging. The imaging modality reported here holds significant potential as a strategy for biomedical imaging of living subjects.
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Cites
Raman spectra of pyridine adsorbed at a silver electrode
Fleischmann, M., Hendra, P. J., & McQuillan, A. J. (1974) · Chemical Physics Letters · doi:10.1016/0009-2614(74)85388-1 · Cited by 7,172
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Nel, A. E., Mädler, L., Velegol, D., Xia, T., Hoek, E. M. V., Somasundaran, P., Klaessig, F., Castranova, V., & Thompson, M. (2009) · Nature Materials · doi:10.1038/nmat2442 · Cited by 7,083
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Ratiometric optical nanoprobes enable accurate molecular detection and imaging
Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 820
Zavaleta, C. L., Smith, B. R., Walton, I., Doering, W., Davis, G., Shojaei, B., Natan, M. J., & Gambhir, S. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813327106 · Cited by 714
Self-citationNanocarbons for Biology and Medicine: Sensing, Imaging, and Drug Delivery
Panwar, N., Soehartono, A. M., Chan, K. K., Zeng, S., Xu, G., Qu, J., Coquet, P., Yong, K.-T., & Chen, X. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00099 · Cited by 555
Metadata
- Authors
- Keren, S., Zavaleta, C., Cheng, Z., de la Zerda, A., Gheysens, O., & Gambhir, S. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-04-15
- Volume
- 105
- Issue
- 15
- Pages
- 5844-5849
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2044279302
- Cited by
- 604
- References
- 1
- FWCI
- 27.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Keren, S., Zavaleta, C., Cheng, Z., de la Zerda, A., Gheysens, O., & Gambhir, S. S. (2008). Noninvasive molecular imaging of small living subjects using Raman spectroscopy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0710575105
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