The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity
Open accessAbstract
During exercise, defects in calcium (Ca 2+ ) release have been proposed to impair muscle function. Here, we show that during exercise in mice and humans, the major Ca 2+ release channel required for excitation–contraction coupling (ECC) in skeletal muscle, the ryanodine receptor (RyR1), is progressively PKA-hyperphosphorylated, S -nitrosylated, and depleted of the phosphodiesterase PDE4D3 and the RyR1 stabilizing subunit calstabin1 (FKBP12), resulting in “leaky” channels that cause decreased exercise tolerance in mice. Mice with skeletal muscle-specific calstabin1 deletion or PDE4D deficiency exhibited significantly impaired exercise capacity. A small molecule (S107) that prevents depletion of calstabin1 from the RyR1 complex improved force generation and exercise capacity, reduced Ca 2+ -dependent neutral protease calpain activity and plasma creatine kinase levels. Taken together, these data suggest a possible mechanism by which Ca 2+ leak via calstabin1-depleted RyR1 channels leads to defective Ca 2+ signaling, muscle damage, and impaired exercise capacity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Quercetin Reduces Illness but Not Immune Perturbations after Intensive Exercise
NIEMAN, D. C., HENSON, D. A., GROSS, S. J., JENKINS, D. P., DAVIS, J. M., MURPHY, E. A., CARMICHAEL, M. D., DUMKE, C. L., UTTER, A. C., MCANULTY, S. R., et al. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318076b566 · Cited by 193 · cited 1×
“Briefly, human subjects underwent an intensive cycling protocol consisting of three consecutive days of cycling for 3 hours at 70% VO2max (18).”
Self-citation
Cited by
Protein S-nitrosylation in health and disease: a current perspective
Foster, M. W., Hess, D. T., & Stamler, J. S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.06.007 · Cited by 752
Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging
Andersson, D. C., Betzenhauser, M. J., Reiken, S., Meli, A. C., Umanskaya, A., Xie, W., Shiomi, T., Zalk, R., Lacampagne, A., & Marks, A. R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.014 · Cited by 424
Allen, D. G., Whitehead, N. P., & Froehner, S. C. (2016) · Physiological Reviews · doi:10.1152/physrev.00007.2015 · Cited by 426
RyR1 S-Nitrosylation Underlies Environmental Heat Stroke and Sudden Death in Y522S RyR1 Knockin Mice
Durham, W. J., Aracena-Parks, P., Long, C., Rossi, A. E., Goonasekera, S. A., Boncompagni, S., Galvan, D. L., Gilman, C. P., Baker, M. R., Shirokova, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.042 · Cited by 351
Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?
Baumann, C. W., Kwak, D., Liu, H. M., & Thompson, L. V. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00321.2016 · Cited by 169
Metadata
- Authors
- Bellinger, A. M., Reiken, S., Dura, M., Murphy, P. W., Deng, S.-X., Landry, D. W., Nieman, D., Lehnart, S. E., Samaru, M., LaCampagne, A., & Marks, A. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-02-12
- Volume
- 105
- Issue
- 6
- Pages
- 2198-2202
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2139337253
- Cited by
- 352
- References
- 1
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity. https://app.cochat.ai/papers/10.1073/pnas.0711074105
- The paper
- Bellinger, A. M., Reiken, S., Dura, M., Murphy, P. W., Deng, S.-X., Landry, D. W., Nieman, D., Lehnart, S. E., Samaru, M., LaCampagne, A., & Marks, A. R. (2008). Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0711074105
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
